Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Comparative oral and topical decongestant effects of phenylpropanolamine and d-pseudoephedrine
Autore:
Erickson, CH; McLeod, RL; Mingo, GG; Egan, RW; Pedersen, OF; Hey, JA;
Indirizzi:
Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA Schering Plough Corp Kenilworth NJ USA 07033 st, Kenilworth, NJ 07033 USA
Titolo Testata:
AMERICAN JOURNAL OF RHINOLOGY
fascicolo: 2, volume: 15, anno: 2001,
pagine: 83 - 90
SICI:
1050-6586(200103/04)15:2<83:COATDE>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NASAL HISTAMINE CHALLENGE; ACOUSTIC RHINOMETRY; ALLERGIC RHINITIS; PATENCY; RHINOMANOMETRY; CONGESTION; GEOMETRY; REFLECTIONS; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: McLeod, RL Schering Plough Corp, Res Inst, 2015 Galloping Hill Rd, Kenilworth, NJ 07033 USA Schering Plough Corp 2015 Galloping Hill Rd Kenilworth NJUSA 07033
Citazione:
C.H. Erickson et al., "Comparative oral and topical decongestant effects of phenylpropanolamine and d-pseudoephedrine", AM J RHINOL, 15(2), 2001, pp. 83-90

Abstract

Nonselective adrenergic alpha -agonists such as phenylpropanolamine and d-pseudoephedrine are widely used as decongestants to treat nasal congestion associated with a variety of nasal diseases. Although the activity of thesedrugs is well established in clinical studies, a direct comparison of their nasal decongestant effect as determined by changes in nasal cavity dimensions and nasal architecture has not been studied. Using acoustic rhinometry, we evaluated the effects of these drugs on nasal cavity volume, minimum cross-sectional area (A(min)), and the distance from the nosepiece to the A(min) (D-min) in a feline, pharmacological model of nasal congestion Administration of topical compound 48/80 (1%), a mast cell histamine liberator, into the left nasal passageway decreased nasal volume by 66%, reduced A(min) by 51%, and increased D-min by 116%. The congestive responses to compound 48/80 (1%) were reproducible through six weeks. In a subset of cats, the nasal cavity volume effect of repetitive exposure to compound 48/80, given once every two weeks for six weeks, was not different from the nasal responsesafter the initial exposure to compound 48/80. Pretreatment with oral phenylpropanolamine (10 mg/kg) or oral d-pseudoephedrine (10 mg/kg) attenuated the nasal effects of compound 48/80, but were associated with a pronounced increase in systolic blood pressure of +51 and +82 mmHg, respectively. A similar decongestant profile was observed with phenylpropanolamine (1%) and d-pseudoephedrine (1%) when given topically. Topical phenylpropanolamine (1%)and d-pseudoephedrine (1%) 45 minutes after dosing increased blood pressure +44 and +17 mmHg, respectively, over control animals. We conclude that oral and topical phenylpropanolamine and d-pseudoephedrine display equieffective nasal decongestant activity and produce similar cardiovascular profilescharacterized by significant increases in blood pressure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 09:05:15