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Titolo:
Evaluation of respiratory gases and acid-base gradients in human fetal fluids and uteroplacental tissue between 7 and 16 weeks' gestation
Autore:
Jauniaux, E; Watson, A; Burton, G;
Indirizzi:
Royal Free & Univ Coll Med, Sch Med, Dept Obstet & Gynaecol, London, England Royal Free & Univ Coll Med London England t & Gynaecol, London, England Univ Cambridge, Dept Anat, Cambridge CB2 3DY, England Univ Cambridge Cambridge England CB2 3DY nat, Cambridge CB2 3DY, England
Titolo Testata:
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
fascicolo: 5, volume: 184, anno: 2001,
pagine: 998 - 1003
SICI:
0002-9378(200104)184:5<998:EORGAA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-PLACENTA; FIRST-TRIMESTER; HUMAN-PREGNANCY; BLOOD-GASES; FETUSES; BALANCE; AGE;
Keywords:
amniotic; coelomic; placenta; acid-base balance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Jauniaux, E Univ Coll London, Sch Med, Dept Obstet & Gynaecol, 86-96 Chenies Mews, London WC1E 6HX, England Univ Coll London 86-96 Chenies Mews London England WC1E 6HX d
Citazione:
E. Jauniaux et al., "Evaluation of respiratory gases and acid-base gradients in human fetal fluids and uteroplacental tissue between 7 and 16 weeks' gestation", AM J OBST G, 184(5), 2001, pp. 998-1003

Abstract

OBJECTIVE: Our purpose was to evaluate the changes in intrauterine gases and acid-base gradients inside the human fetoplacental unit at 7 to 16 weeks' gestation. STUDY DESIGN: Respiratory gases and acid-base values were recorded by means of a multiparameter sensor and samples from inside the exocoelomic or amniotic cavity, placental tissue, decidua, and fetal blood of 30 early pregnancies. RESULTS: Before 11 weeks' gestation, placental P-O2 was 2.5 times lower than decidual P-O2. The P-O2 increased independently at both sites during gestation, but a P-O2 gradient of 13.3 mm Hg persisted during the fourth month. At 13 to 16 weeks, P-O2, oxygen saturation, and oxygen content gradients were observed between the fetal blood and the placenta and between the placenta and underlying decidual tissue. There was no fetoplacental gradient for pH and P-CO2 between 7 and 16 weeks, but fetal blood pH values were much lower and fetal P-CO2 values were much higher than those reported in older fetuses. CONCLUSIONS: Early human placental tissue develops in a physiologically low-oxygen environment compared with uterine tissue. This may be necessary toallow specific placental metabolic activities and to protect both placental and fetal tissues against toxic oxygen metabolites.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:17:56