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Titolo:
Tumor- and treatment-related side effects after multimodal therapy of childhood intracranial germ cell tumors
Autore:
Benesch, M; Lackner, H; Schagerl, S; Gallistl, S; Frey, EM; Urban, C;
Indirizzi:
Graz Univ, Dept Paediat, Div Paediat Haematol & Oncol, AT-8036 Graz, Austria Graz Univ Graz Austria AT-8036 t Haematol & Oncol, AT-8036 Graz, Austria Graz Univ, Dept Paediat, Div Gen Paediat, AT-8036 Graz, Austria Graz UnivGraz Austria AT-8036 t, Div Gen Paediat, AT-8036 Graz, Austria St Anna Childrens Hosp, A-1090 Vienna, Austria St Anna Childrens Hosp Vienna Austria A-1090 osp, A-1090 Vienna, Austria
Titolo Testata:
ACTA PAEDIATRICA
fascicolo: 3, volume: 90, anno: 2001,
pagine: 264 - 270
SICI:
0803-5253(200103)90:3<264:TATSEA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; IMPROVED PROGNOSIS; RADIATION-THERAPY; CHILDREN; IRRADIATION; GERMINOMA; CISPLATIN; CNS;
Keywords:
childhood; endocrine deficiencies; intracranial germ cell tumors; multimodality therapy; side effects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Benesch, M Graz Univ, Dept Paediat, Div Paediat Haematol & Oncol, Auenbruggerpl 30, AT-8036 Graz, Austria Graz Univ Auenbruggerpl 30 Graz Austria AT-8036 Graz, Austria
Citazione:
M. Benesch et al., "Tumor- and treatment-related side effects after multimodal therapy of childhood intracranial germ cell tumors", ACT PAEDIAT, 90(3), 2001, pp. 264-270

Abstract

Multimodality treatment approaches have dramatically improved the outcome of patients with intracranial germ cell tumors and are resulting in an increasing number of long-term survivors. The aim of the present study was to evaluate prospectively the development of side effects in children, adolescents and young adults after treatment for intracranial germ cell tumors. Nine patients with a median age of 14 y at diagnosis and a median follow-up of7.25 y underwent a detailed long-term evaluation including physical and neuro-ophthalmologic examinations, routine laboratory and endocrine stimulation tests, neuropsychometric testing, audiometry and spirometry at repeated intervals. Endocrine deficiencies requiring hen-none replacement therapy occurred in all patients. Neuro-ophthalmologic side effects were observed in 8 of the 9 patients, urinary electrolyte wasting in 4 of the 9, alopecia in3 of the 9 and high-frequency hearing loss in 2 of the 9. Neuropsychologicexaminations revealed pathologic results in all five tested patients. Conclusion: The present study indicates that former intracranial germ celltumur patients suffer from remarkable long-term side effects, and that some of these late effects can develop or worsen months or years after cessation of oncologic therapy. Since life quality is an important parameter of cancer survival, careful follow-up of long-term survivors is mandatory, aimedat counteracting side effects as early as possible and therefore at minimizing long-term morbidity, which may considerably compromise quality of life.

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Documento generato il 30/11/20 alle ore 16:44:13