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Titolo:
Genetic polymorphisms in older subjects with vascular or Alzheimer's dementia
Autore:
Zuliani, G; Ble, A; Zanca, R; Munari, MR; Zurlo, A; Vavalle, C; Atti, AR; Fellin, R;
Indirizzi:
Univ Ferrara, Ist Med Interna 2, Dept Internal Med 2, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 nternal Med 2, I-44100 Ferrara, Italy Ca Foncello Hosp, Long Term Div, Treviso, Italy Ca Foncello Hosp TrevisoItaly ello Hosp, Long Term Div, Treviso, Italy S Anna Hosp, Div Geriatr, Ferrara, Italy S Anna Hosp Ferrara ItalyS Anna Hosp, Div Geriatr, Ferrara, Italy
Titolo Testata:
ACTA NEUROLOGICA SCANDINAVICA
fascicolo: 5, volume: 103, anno: 2001,
pagine: 304 - 308
SICI:
0001-6314(200105)103:5<304:GPIOSW>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; APOLIPOPROTEIN-E; DELETION POLYMORPHISM; MYOCARDIAL-INFARCTION; RISK FACTOR; CEREBROVASCULAR-DISEASE; ASSOCIATION; PARAOXONASE; POPULATION;
Keywords:
paraoxonase; angiotensin-converting enzyme; methylenetetrahydrofolate reductase; apolipoprotein E; dementia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Fellin, R Univ Ferrara, Ist Med Interna 2, Dept Internal Med 2, Via Savonarole 9, I-44100 Ferrara, Italy Univ Ferrara Via Savonarole 9 Ferrara ItalyI-44100 rara, Italy
Citazione:
G. Zuliani et al., "Genetic polymorphisms in older subjects with vascular or Alzheimer's dementia", ACT NEUR SC, 103(5), 2001, pp. 304-308

Abstract

Objectives - Paraoxonase, angiotensin-converting enzyme (ACE), methylenetetrahydrofolate reductase (MTHFR), and apo E gene polymorphisms were evaluated in older patients with vascular dementia (VD) or late-onset Alzheimer's disease (LOAD). Material and methods Sixty patients with VD, 45 patients with LOAD, and 54 non-demented controls were compared. Results - No differences in the distribution of paraoxonase, ACE, and MTHFR polymorphisms were found. The overall frequency of apo E epsilon4 allele was "low"; epsilon4 allele was more frequent in LOAD (17.5%) and VD (13.3%) compared with controls(9.2%), but the difference was not statistically significant. Conclusion Paraoxonase, ACE, and MTHFR polymorphisms were not associated with VD or LOAD; these common polymorphisms might have a marginal role in the pathogenesis of dementia in older subjects. In spite of a "low" frequency of the apo Eepsilon4 allele in our sample, the frequency of epsilon4 allele was about double in LOAD compared with controls.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:56:03