Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Caged and clustered structures of endothelin inhibitor BQ123, cyclo(-D-Trp-D-Asp(-)-Pro-D-Val-Leu-)center dot Na+, forming five and six coordination bonds between sodium ions and peptides
Autore:
Doi, M; Asano, A; Ishida, T; Katsuya, Y; Mezaki, Y; Sasaki, M; Terashima, A; Taniguchi, T; Hasegawa, H; Shiono, M;
Indirizzi:
Osaka Univ Pharmaceut Sci, Takatsuki, Osaka 5691094, Japan Osaka Univ Pharmaceut Sci Takatsuki Osaka Japan 5691094 ka 5691094, Japan Hyogo Prefectural Inst Ind Res, Kobe, Hyogo 6540037, Japan Hyogo Prefectural Inst Ind Res Kobe Hyogo Japan 6540037 go 6540037, Japan Hyogo Inst Aging Brain & Cognit Disorders, Himeji, Hyogo 6700981, Japan Hyogo Inst Aging Brain & Cognit Disorders Himeji Hyogo Japan 6700981 apan Kyushu Univ, Higashi Ku, Fukuoka 8128581, Japan Kyushu Univ Fukuoka Japan 8128581 iv, Higashi Ku, Fukuoka 8128581, Japan
Titolo Testata:
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
, volume: 57, anno: 2001,
parte:, 5
pagine: 628 - 634
SICI:
0907-4449(200105)57:<628:CACSOE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
A RECEPTOR ANTAGONISTS; CRYSTAL-STRUCTURE; BINDING INHIBITORS; POTENT; BE-18257A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Doi, M Osaka Univ Pharmaceut Sci, 4-20-1 Nasahara, Takatsuki, Osaka 5691094, Japan Osaka Univ Pharmaceut Sci 4-20-1 Nasahara Takatsuki Osaka Japan 5691094
Citazione:
M. Doi et al., "Caged and clustered structures of endothelin inhibitor BQ123, cyclo(-D-Trp-D-Asp(-)-Pro-D-Val-Leu-)center dot Na+, forming five and six coordination bonds between sodium ions and peptides", ACT CRYST D, 57, 2001, pp. 628-634

Abstract

BQ123 is a cyclic pentapeptide and a potent endothelin-1 inhibitor. The crystal structure of the BQ123 sodium salt was determined as the first example of an endothelin inhibitor. Four independent molecules and many solvent molecules were found in the asymmetric unit; the total weight was about 3000Da. The precise structure including the solvent molecules was determined using high-resolution data collected on a synchrotron source. Sodium ions formed unique structures with five and six coordination bonds and their formswere distinguished into three classes. An ion was sandwiched by two BQ123 molecules. This peptide-sodium (2:1) complex showed a cage-like structure and octahedral coordination was observed. Sodium ions also formed a cluster composed of hydrated water molecules and peptides. Two sodium ions were contained in this cluster, making five coordination bonds. Despite having the same coordination numbers, these ions were distinguishable by differences in the polyhedra. One was trigonal bipyramidal (having six planes) and the other was square pyramidal (having five planes). Both shapes were very similar to each other, although the synchrotron data clearly revealed slight geometrical differences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:11:29