Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Assessment of prediction accuracy of protein function from protein-proteininteraction data
Autore:
Hishigaki, H; Nakai, K; Ono, T; Tanigami, A; Takagi, T;
Indirizzi:
Univ Tokyo, Inst Med Sci,Human Genome Ctr, Lab Genome Database, Minato Ku,Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 Database, Minato Ku,Tokyo 1088639, Japan Otsuka Pharmaceut Co Ltd, Otsuka GEN Res Inst, Tokushima 7710192, Japan Otsuka Pharmaceut Co Ltd Tokushima Japan 7710192 okushima 7710192, Japan
Titolo Testata:
YEAST
fascicolo: 6, volume: 18, anno: 2001,
pagine: 523 - 531
SICI:
0749-503X(200104)18:6<523:AOPAOP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
YEAST; SEQUENCES; GENOMICS; SYSTEM; MAP;
Keywords:
Saccharomyces cerevisiae; protein-protein interaction; systematic analysis; protein interaction map; functional prediction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Takagi, T Univ Tokyo, Inst Med Sci,Human Genome Ctr, Lab Genome Database, Minato Ku,4-6-1 Shirokanedai, Tokyo 1088639, Japan Univ Tokyo 4-6-1 Shirokanedai Tokyo Japan 1088639 088639, Japan
Citazione:
H. Hishigaki et al., "Assessment of prediction accuracy of protein function from protein-proteininteraction data", YEAST, 18(6), 2001, pp. 523-531

Abstract

Functional prediction of open reading frames coded in the genome is one ofthe most important tasks in yeast genomics. Among a number of large-scale experiments for assigning certain functional classes to proteins, experiments determining protein-protein interaction are especially important becauseinteracting proteins usually have the same function. Thus, it seems possible to predict the function of a protein when the function of its interacting partner is known. However, in vitro experiments often suffer from artifacts and a protein can often have multiple binding partners with different functions. We developed an objective prediction method that can systematically include the information of indirect interaction. Our method can predict the subcellular localization, the cellular role and the biochemical functionof yeast proteins with accuracies of 72.7%, 63.6% and 52.7%, respectively. The prediction accuracy rises for proteins with more than three binding partners and thus me present the open prediction results for 16 such proteins. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:24:07