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Titolo:
The P2X7 purinergic receptor on bovine macrophages mediates mycobacterial death
Autore:
Smith, RA; Alvarez, AJ; Estes, DM;
Indirizzi:
Univ Missouri, Coll Vet Med, Dept Vet Pathobiol, Program Prevent Anim Infect Dis, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 im Infect Dis, Columbia, MO 65211 USA
Titolo Testata:
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
fascicolo: 3-4, volume: 78, anno: 2001,
pagine: 249 - 262
SICI:
0165-2427(20010210)78:3-4<249:TPPROB>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR ATP; DENDRITIC CELLS; NUCLEOTIDE RECEPTOR; PLASMA-MEMBRANE; T-LYMPHOCYTES; P2Z RECEPTOR; P2X(7); RELEASE; PURINOCEPTOR; INFLAMMATION;
Keywords:
P2X7; ATP; Mycobacterium bovis; macrophage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Estes, DM Univ Missouri, Coll Vet Med, Dept Vet Pathobiol, Program PreventAnim Infect Dis, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 Dis, Columbia, MO 65211 USA
Citazione:
R.A. Smith et al., "The P2X7 purinergic receptor on bovine macrophages mediates mycobacterial death", VET IMMUNOL, 78(3-4), 2001, pp. 249-262

Abstract

P2X7 is an ATP gated purinoceptor that has been linked to various immune responses. P2X7 appears to be expressed ubiquitously in the immune system and thus may be important as an effector pathway or play significant roles incell activation/death. 2',3'-(4-Benzoyl)benzoyl ATP is the most potent agonist of this receptor and ATP in its fully dissociated form (ATP(4-)) also activates the receptor. High concentrations of ATP can cause the P2X7 receptor to induce pore formation on the surface of the cell that allows molecules of considerable size to pass and can lead to cell death. The P2X7 receptor has also been linked to various immune activities when the concentrationof ATP is lower, including the release of IL-1 beta. The role P2X7 receptors have on immune cell activities is just beginning to be understood. We sought to determine the role of P2X7 on bovine macrophages in eliminating thecausative agent of bovine-type tuberculosis, Mycobacterium bovis. Because high concentrations of ATP are linked to macrophage death, we determined ifthis method of cell destruction also leads to reduced bacterial viability. We find that P2X7 is present on bovine macrophages from different sources,including both peripheral blood-derived as well as alveolar macrophages. In addition, P2X7 mRNA is present in B and T lymphocytes. The treatment of M. bovis-infected macrophages with ATP results in reduced macrophage viability as well as reduced M. bovis viability, (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 12:47:36