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Titolo:
Assessment of endothelial function in normal twin pregnancy
Autore:
Savvidou, MD; Donald, AE; Nicolaides, KH;
Indirizzi:
Kings Coll Hosp, Harris Birhtright Res Ctr Fetal Med, London, England Kings Coll Hosp London England right Res Ctr Fetal Med, London, England Great Ormond St Hosp Children, Cardiothorac Unit, London, England Great Ormond St Hosp Children London England orac Unit, London, England
Titolo Testata:
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
fascicolo: 3, volume: 17, anno: 2001,
pagine: 220 - 223
SICI:
0960-7692(200103)17:3<220:AOEFIN>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLOW-MEDIATED VASODILATION; NITRIC-OXIDE SYNTHASES; POSTMENOPAUSAL WOMEN; RISK-FACTORS; ESTROGEN; PREECLAMPSIA; CORONARY; ACETYLCHOLINE; RESPONSES; INDUCTION;
Keywords:
endothelium; nitric oxide; pregnancy; twins; ultrasound;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Nicolaides, KH Kings Coll Hosp, Harris Birhtright Res Ctr Fetal Med, Denmark Hill, London, England Kings Coll Hosp Denmark Hill London England ndon, England
Citazione:
M.D. Savvidou et al., "Assessment of endothelial function in normal twin pregnancy", ULTRASOUN O, 17(3), 2001, pp. 220-223

Abstract

Objective To assess the maternal endothelial function in normal twin pregnancy. Design Cross-sectional study. Subjects Endothelial function was investigated in 74 women with normal twin pregnancy at 11-30 weeks of gestation and the results were compared to previous reported findings in 98 women with normal singleton pregnancy and 19nonpregnant controls. Methods Endothelial function was assessed by measuring the changes of the brachial artery diameter in response to reactive hyperemia (flow-mediated dilatation) using external high resolution ultrasound. Results Flow-mediated dilatation of the brachial artery in both twin and singleton pregnancies was significantly higher than in non-pregnant women (P= 0.002 and P = 0.02, respectively). However, there was no significant difference in flow-mediated dilatation between women with twin and singleton pregnancy (9.61 +/- 4.36 vs. 8.84 +/- 3.18, P = 0.38). Resting vessel size, baseline flour and reactive hyperemia did not change significantly with gestation in twin pregnancy and were similar to values in singleton pregnancies and controls. Conclusion Our findings indicate that although in pregnancy endothelial function is enhanced, this change may not be affected by the number of fetoplacental units present.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 02:34:46