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Titolo:
Outcome of first-trimester chorionic villus sampling for genetic investigation in multiple pregnancy
Autore:
Brambati, B; Tului, L; Guercilena, S; Alberti, E;
Indirizzi:
Univ Milan, Dept OB GYN 1, I-20122 Milan, Italy Univ Milan Milan Italy I-20122 ilan, Dept OB GYN 1, I-20122 Milan, Italy Univ Milan, Ctr Prenatal Diag, I-20122 Milan, Italy Univ Milan Milan Italy I-20122 , Ctr Prenatal Diag, I-20122 Milan, Italy Univ Milan, Inst Occupat Hlth, Epidemiol Unit, I-20122 Milan, Italy Univ Milan Milan Italy I-20122 lth, Epidemiol Unit, I-20122 Milan, Italy
Titolo Testata:
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
fascicolo: 3, volume: 17, anno: 2001,
pagine: 209 - 216
SICI:
0960-7692(200103)17:3<209:OOFCVS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCHAL TRANSLUCENCY THICKNESS; TWIN PREGNANCIES; PRENATAL-DIAGNOSIS; 2ND-TRIMESTER AMNIOCENTESIS; SELECTIVE TERMINATION; MEMBRANE THICKNESS; PEAK SIGN; GESTATIONS; AMNIONICITY; PREDICTION;
Keywords:
first-trimester genetic diagnosis; multiple pregnancy; chorionic villus sampling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Brambati, B Univ Milan, Dept OB GYN 1, Via Commenda 12, I-20122 Milan, Italy Univ Milan Via Commenda 12 Milan Italy I-20122 2 Milan, Italy
Citazione:
B. Brambati et al., "Outcome of first-trimester chorionic villus sampling for genetic investigation in multiple pregnancy", ULTRASOUN O, 17(3), 2001, pp. 209-216

Abstract

Objectives To evaluate the efficacy of and risk associated with chorionic villus sampling for genetic investigations in multiple pregnancies, and to evaluate the accuracy of the ultrasonographic detection of chorionicity during the first trimester. Patients and Methods A total of 198 sets of twins and nine sets of triplets from 10 087 consecutive first-trimester pregnancies undergoing chorionic villus sampling were considered. Gestational age ranged from 7 to 12.6 weeks. Assessment and confirmation of chorionicity was based on a multiplicity of features. Dichorionicity was established in 169 sets of twins (85.3%) and trichorionicity in all triplet cases, while 29 twins were considered monochorionic. Chorionic villus sampling was performed transabdominally in all but one case, and identification of the placental insertion of the umbilical cord was the main benchmark for sampling. Sampling risks were evaluated by comparing clinical outcome with that of a control population of 63 dichorionic twin pregnancies which underwent no invasive procedure. Results Determination of the presence or absence of the lambda sign led toa correct assignment of chorionicity in all cases, while the presence of amembrane thickness of 2 mm or more reflected a 100% specificity with a 22%false negative rate. Sampling was successfully performed in all cases and in only four cases (1.0%) were two needle insertions needed. At follow-up no evidence of incorrect sampling was reported. Karyotyping was provided to all patients, and in 94.1% of cases both short and long-term culture methods were carried out. No difference in fetal and perinatal losses between thestudy and control populations was found, bur a higher rate of deliveries before 37 weeks and of low birth weight babies was noted amongst controls. Conclusions Chorionicity in twin pregnancy can be determined with certainty between 7 and 12 weeks of gestation; in cases of confluent placentas reliability is provided by determining the presence or absence of the lambda sign. This study indicates that first-trimester transabdominal chorionic villus sampling is a highly efficient, reliable, and relatively safe approach for genetic diagnosis in twin pregnancies. Although a precise evaluation of the relative risks of chorionic villus sampling and mid-trimester amniocentesis in twins must await randomized control studies, the advantages of a first-trimester diagnosis to enable early decision-making about selective fetal reduction are obvious.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 23:31:11