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Titolo:
Preparation of (R)- and (S)-4-chloro-3-acetoxybutyronitrile using microbial resolution
Autore:
Idogaki, H; Kasai, N; Takeuchi, M; Hatada, M; Suzuki, T;
Indirizzi:
Daiso Co Ltd, Res Labs, Amagasaki, Hyogo 6600842, Japan Daiso Co Ltd Amagasaki Hyogo Japan 6600842 magasaki, Hyogo 6600842, Japan Univ Osaka Prefecture, Fac Agr, Sakai, Osaka 5998531, Japan Univ Osaka Prefecture Sakai Osaka Japan 5998531 kai, Osaka 5998531, Japan
Titolo Testata:
TETRAHEDRON-ASYMMETRY
fascicolo: 3, volume: 12, anno: 2001,
pagine: 369 - 373
SICI:
0957-4166(20010305)12:3<369:PO(A(U>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HMG-COA REDUCTASE; (S)-2,3-DICHLORO-1-PROPANOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Kasai, N Daiso Co Ltd, Res Labs, 9 Otakasu Cho, Amagasaki, Hyogo 6600842, Japan Daiso Co Ltd 9 Otakasu Cho Amagasaki Hyogo Japan 6600842 2, Japan
Citazione:
H. Idogaki et al., "Preparation of (R)- and (S)-4-chloro-3-acetoxybutyronitrile using microbial resolution", TETRAHEDR-A, 12(3), 2001, pp. 369-373

Abstract

A new preparation of optically active 4-chloro-3-acetoxybutyronitrile (AcBN) was developed using the resting cells of bacteria. The resolution was based on enantioselective hydrolysis of the ester function of the substrate. (R)-AcBN was prepared using Pseudomonas sp. DS-K-717, and the resulting (R)-AcBN was obtained with high enantiomeric excess of >98% with a yield of 36% during the microbial resolution step. (S)-AcBN was prepared in the same manner using the resting cells of Pseudomonas sp. DS-K-19 and showed a high enantiomeric excess of >98%, with a yield of 32%. The enzyme activity was enhanced and induced by the addition of AcBN, particularly the (R)-ester hydrolysis, which was enhanced 20-fold. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:29:09