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Titolo:
Comparison of the effects of atipamezole and tolazoline on analgesia, cardiopulmonary and rectal temperature changes induced by lumbosacral epidural injection of medetomidine in goats
Autore:
Mpanduji, DG; Bittegeko, SBP; Batamuzi, EK; Mgasa, MN; Shami, CL;
Indirizzi:
Sokoine Univ Agr, Dept Vet Surg & Theriogenol, Morogoro, Tanzania Sokoine Univ Agr Morogoro Tanzania rg & Theriogenol, Morogoro, Tanzania
Titolo Testata:
SMALL RUMINANT RESEARCH
fascicolo: 2, volume: 40, anno: 2001,
pagine: 117 - 122
SICI:
0921-4488(200105)40:2<117:COTEOA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
YOHIMBINE; XYLAZINE;
Keywords:
lumbosacral epidural; medetomidine; atipamezole; tolazoline; goats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Mpanduji, DG Sokoine Univ Agr, Dept Vet Surg & Theriogenol, POB 3020, Morogoro, Tanzania Sokoine Univ Agr POB 3020 Morogoro Tanzania ogoro, Tanzania
Citazione:
D.G. Mpanduji et al., "Comparison of the effects of atipamezole and tolazoline on analgesia, cardiopulmonary and rectal temperature changes induced by lumbosacral epidural injection of medetomidine in goats", SMALL RUMIN, 40(2), 2001, pp. 117-122

Abstract

The present study was carried out in order to compare the reversing effects of alpha -adrenergic receptor antagonists, atipamezole and tolazoline on analgesia, cardiopulmonary depression and rectal temperature changes induced by epidural administration of medetomidine in gents. Eight clinically healthy, small East African goats of both sexes weighing between 12 and 17 kg (mean +/- 1.8 kg) were used in this study. The animals were randomly divided into two groups of Four animals. The first group was given 20 mug/kg medetomidine followed by intravenous (IV) administration of 80 mug/kg atipamezole. 30 min after the initial injection. The second group was given same treatment for medetomidine as group one but followed by IV administration of 2.2 mg/kg tolazoline, 30 min after the initial injection. In both treatment groups, medetomidine was administered epidurally through the lumbosacral interspace. Analgesia of the flank and perineum was evaluated at every 10 minintervals up to 60 min. The cardiopulmonary and rectal temperature values were monitored and recorded at every 5 min interval up to 60 min. In both groups, lumbosacral epidural injection of medetomidine induced generalised analgesia, variable cardiopulmonary depression effects and non-significant changes on rectal temperature. These changes developed as early as 5 min andcontinued until alpha (2)/alpha (1) antagonists were administered. Intravenous administration of cr-adrenergic receptor antagonists; atipamezole and tolazoline reversed analgesia, cardiopulmonary and rectal temperature changes induced by lumbosacral epidural injection of medetomidine in goats. However, atipamezole appeared to be superior (P < 0.05) to tolazoline. From this study, it was concluded that IV administration of 80 <mu>g/kg atipamezolewas better than 2.2 mg/kg tolazoline in reversing analgesia and cardiopulmonary depression effects induced by lumbosacral epidural injection of medetomidine in gents. This indicates the superiority of atipamezole to tolazoline as an antidote for medetomidine induced effects in goats. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 08:06:19