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Titolo:
Immune evasion as a pathogenic mechanism of varicella zoster virus
Autore:
Abendroth, A; Arvin, AM;
Indirizzi:
Stanford Univ, Sch Med, Dept Pediat Infect Dis, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 at Infect Dis, Stanford, CA 94305 USA Westmead Millenium Inst, Ctr Virus Res, Westmead, NSW 2145, Australia Westmead Millenium Inst Westmead NSW Australia 2145 , NSW 2145, Australia
Titolo Testata:
SEMINARS IN IMMUNOLOGY
fascicolo: 1, volume: 13, anno: 2001,
pagine: 27 - 39
SICI:
1044-5323(200102)13:1<27:IEAAPM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
I HEAVY-CHAINS; MOUSE CYTOMEGALOVIRUS GLYCOPROTEIN; INHIBITS PEPTIDE TRANSLOCATION; CD8(+) T-LYMPHOCYTES; SCID-HU MOUSE; ANTIGEN PRESENTATION; INTERFERON-GAMMA; ENDOPLASMIC-RETICULUM; TRANSACTIVATOR GENE; MHC MOLECULES;
Keywords:
immunomodulation; MHC class I; MHC class II; varicella zoster virus;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Arvin, AM Stanford Univ, Sch Med, Dept Pediat Infect Dis, 300 Pasteur Dr,Rm G312, Stanford, CA 94305 USA Stanford Univ 300 Pasteur Dr,Rm G312 Stanford CA USA 94305 5 USA
Citazione:
A. Abendroth e A.M. Arvin, "Immune evasion as a pathogenic mechanism of varicella zoster virus", SEMIN IMMUN, 13(1), 2001, pp. 27-39

Abstract

Varicella zoster virus (VZV) is a human herpesvirus that causes varicella (chickenpox) during primary infection, establishes latency in dorsal root ganglia and may reactivate years later, producing herpes zoster. VZV must evade antiviral immunity during three important stages of viral pathogenesis,including the cell-associated viremia characteristic of primary infection,persistence in dorsal root ganglia during latency and the initial period of VZV reactivation. Our observations about the immunomodulatory effects of VZV document its capacity to interfere with adaptive immunity mediated by CD4 as well as CD8 T cells, ensuring the survival of the virus in the human population from generation to generation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 13:40:09