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Titolo:
Co-stimulation and counter-stimulation: lipid raft clustering controls TCRsignaling and functional outcomes
Autore:
Miceli, MC; Moran, M; Chung, CD; Patel, VP; Low, T; Zinnanti, W;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Dept Microbiol Mol Genet & Immunol, Mol Biol Inst 508, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los AngelesCA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
SEMINARS IN IMMUNOLOGY
fascicolo: 2, volume: 13, anno: 2001,
pagine: 115 - 128
SICI:
1044-5323(200104)13:2<115:CACLRC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL RECEPTOR; PROTEIN-TYROSINE KINASES; INSOLUBLE MEMBRANE DOMAINS; THYMIC EPITHELIAL-CELLS; SRC HOMOLOGY-2 DOMAIN; ANTIGEN RECEPTOR; ZETA-CHAIN; ACTIN CYTOSKELETON; IL-2 PRODUCTION; DEFICIENT MICE;
Keywords:
lipid rafts; TCR; costimulation; counter-stimulation; immune synapse;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
107
Recensione:
Indirizzi per estratti:
Indirizzo: Miceli, MC Univ Calif Los Angeles, Sch Med, Dept Microbiol Mol Genet & Immunol, Mol Biol Inst 508, 405 Hilgard Ave, Los Angeles, CA 90095 USA Univ Calif Los Angeles 405 Hilgard Ave Los Angeles CA USA 90095
Citazione:
M.C. Miceli et al., "Co-stimulation and counter-stimulation: lipid raft clustering controls TCRsignaling and functional outcomes", SEMIN IMMUN, 13(2), 2001, pp. 115-128

Abstract

T cell receptor (TCR) antigen recognition induces the formation of a specialized 'immunological synapse' at the T cell:antigen presenting cell (APC) junction. This junction is generated by the recruitment and exclusion of particular proteins from the contact area and is required for T cell activation. We and others have hypothesized that lipid raft/non-raft partitioning provides a molecular basis for protein sorting which organizes the TCR, co-stimulators, signal transducers and the actin cytoskeleton at the T cell:APCinterface. Here we discuss the emerging paradigm that co-stimulators induce the directional transport and clustering of lipid rafts at the T cell:APCinterface, thus generating platform(s) specialized for processive and sustained TCR signal transduction and T cell activation. We also discuss recentdata implicating the involvement of 'counter-stimulators' and other negative regulators which prevent optimal raft clustering at the TCR contact siteand, thus, facilitate T cell inactivation and tolerance induction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 17:09:54