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Titolo:
Raft membrane domains: from a liquid-ordered membrane phase to a site of pathogen attack
Autore:
van der Goot, FG; Harder, T;
Indirizzi:
Univ Geneva, Dept Biochem, CH-1211 Geneva, Switzerland Univ Geneva Geneva Switzerland CH-1211 chem, CH-1211 Geneva, Switzerland Basel Inst Immunol, CH-4005 Basel, Switzerland Basel Inst Immunol Basel Switzerland CH-4005 CH-4005 Basel, Switzerland
Titolo Testata:
SEMINARS IN IMMUNOLOGY
fascicolo: 2, volume: 13, anno: 2001,
pagine: 89 - 97
SICI:
1044-5323(200104)13:2<89:RMDFAL>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GPI-ANCHORED PROTEINS; PLASMA-MEMBRANE; CELL-SURFACE; BIOLOGICAL-MEMBRANES; LIPID RAFTS; SIGNAL-TRANSDUCTION; CHOLERA-TOXIN; ESCHERICHIA-COLI; EPITHELIAL-CELLS; MODEL MEMBRANES;
Keywords:
membrane rafts; liquid-ordered membrane phases; cholesterol; host-pathogen interactions;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: van der Goot, FG Univ Geneva, Dept Biochem, 30 Quai E Ansermet, CH-1211 Geneva, Switzerland Univ Geneva 30 Quai E Ansermet Geneva Switzerland CH-1211
Citazione:
F.G. van der Goot e T. Harder, "Raft membrane domains: from a liquid-ordered membrane phase to a site of pathogen attack", SEMIN IMMUN, 13(2), 2001, pp. 89-97

Abstract

While the existence of cholesterol/sphingolipid (raft) membrane domains inthe plasma membrane is now supported by strong experimental evidence, the structure of these domains, their size, their dynamics, and their molecularcomposition remain to be understood. Raft domains are thought to representa specific physical state of lipid bilayers, the liquid-ordered phase. Recent observations suggest that in the mammalian plasma membrane small raft domains in ordered lipid phases are in a dynamic equilibrium with a less ordered membrane environment. Rafts may be enlarged and/or stabilized by protein-mediated cross-linking of raft-associated components. These changes of plasma membrane structure are perceived by the cells as signals, most likelyan important element of immunoreceptor signalling. Pathogens abuse raft domains on the host cell plasma membrane as concentration devices, as signalling platforms and/or entry sites into the cell. Elucidation of these interactions requires a detailed understanding raft structure and dynamics.

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Documento generato il 29/03/20 alle ore 13:29:05