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Titolo:
Phosphatidylinositol transfer proteins couple lipid transport to phosphoinositide synthesis
Autore:
Cockcroft, S;
Indirizzi:
Univ London Univ Coll, Dept Physiol, London WC1E 6JJ, England Univ London Univ Coll London England WC1E 6JJ , London WC1E 6JJ, England
Titolo Testata:
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
fascicolo: 2, volume: 12, anno: 2001,
pagine: 183 - 191
SICI:
1084-9521(200104)12:2<183:PTPCLT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SECRETORY VESICLE FORMATION; PHOSPHOLIPASE-C ACTIVITY; RETINAL-DEGENERATION-B; SACCHAROMYCES-CEREVISIAE; 4,5-BISPHOSPHATE SYNTHESIS; DEPENDENT PHOSPHORYLATION; CA2+-ACTIVATED SECRETION; HL-60 CELLS; PITP-ALPHA; YEAST;
Keywords:
phospholipase C; membrane traffic; exocytosis; Golgi; lipid kinases;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Cockcroft, S Univ London Univ Coll, Dept Physiol, Rockefeller Bldg,Univ St, London WC1E6JJ, England Univ London Univ Coll Rockefeller Bldg,Univ St London England WC1E 6JJ
Citazione:
S. Cockcroft, "Phosphatidylinositol transfer proteins couple lipid transport to phosphoinositide synthesis", SEM CELL D, 12(2), 2001, pp. 183-191

Abstract

Phosphatidylinositol transfer proteins (PITPs) are lipid binding proteins that can catalyse the transfer of phosphatidylinositol (PI) from membranes enriched in PI fo PI-deficient membranes. Three soluble forms of PITP of 35-38 kDa (PITP alpha, PITP beta and rdgB beta) and two larger,integral proteins of 160 kDa (rdgB alphaI and II), which contain a PITP domain, arp Soundin mammalian cells. PITPs are intimately associated with the compartmentalised synthesis of different phosphorylated inositol lipids. PI is the primary inositol lipid that is synthesised at the endo-plasmic reticulum and is further phosphorylated in distinct membrane compartments by many specific lipid kinases to generate seven phosphorylated inositol lipids which are required for both signalling and for membrane traffic. PITPs play essential roles in both signalling via phospholipase C and phosphoinositide 3-kinases and in multiple aspects of membrane traffic including regulated exocytosis and vesicle biogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:13:15