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Titolo:
Membrane domains and polarized trafficking of sphingolipids
Autore:
Maier, O; Slimane, TA; Hoekstra, D;
Indirizzi:
Univ Groningen, Dept Membrane Cell Biol, NL-9713 AV Groningen, NetherlandsUniv Groningen Groningen Netherlands NL-9713 AV V Groningen, Netherlands
Titolo Testata:
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
fascicolo: 2, volume: 12, anno: 2001,
pagine: 149 - 161
SICI:
1084-9521(200104)12:2<149:MDAPTO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DARBY CANINE KIDNEY; GPI-ANCHORED PROTEINS; RAFT-ASSOCIATED PROTEIN; TRANS-GOLGI NETWORK; CELL-SURFACE OCCURS; PLASMA-MEMBRANE; SUBAPICAL COMPARTMENT; EPITHELIAL-CELLS; HEPG2 CELLS; MDCK CELLS;
Keywords:
cell polarity; (glyco)sphingolipids; membrane transport; rafts; sorting;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Hoekstra, D Univ Groningen, Dept Membrane Cell Biol, Antonius Deusinglaan 1, NL-9713 AV Groningen, Netherlands Univ Groningen Antonius Deusinglaan 1 Groningen Netherlands NL-9713 AV
Citazione:
O. Maier et al., "Membrane domains and polarized trafficking of sphingolipids", SEM CELL D, 12(2), 2001, pp. 149-161

Abstract

The plasma membrane of polarized cells consists of distinct domains, the apical and basolateral membrane that are characterized by a distinct lipid and protein content. Apical protein transport is largely mediated by (glyco)sphingolipid-cholesterol enriched membrane microdomains, so called rafts. In addition changes in the direction of polarized sphingolipid transport appear instrumental in cell polarity development. Knowledge is therefore required of the mechanisms that mediate sphingolipid sorting and the complexity of the trafficking pathways that are involved in polarized transport of both sphingolipids and Proteins. Here rue summarize specific biophysical properties that underly mechanisms relevant to sphingolipid sorting, cargo recruitment and polarized trafficking, and discuss the central role of a subapical compartment, SAC or common endosome (CE), as a major intracellular site involved In polarized sorting of sphingolipids, and in development and maintenance of membrane polarity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:17:29