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Titolo:
Heparan sulfate proteoglycans in invasion and metastasis
Autore:
Sanderson, RD;
Indirizzi:
Univ Arkansas Med Sci, Arkansas Canc Res Ctr, Dept Pathol, Little Rock, AR72205 USA Univ Arkansas Med Sci Little Rock AR USA 72205 , Little Rock, AR72205 USA Univ Arkansas Med Sci, Arkansas Canc Res Ctr, Dept Anat, Little Rock, AR 72205 USA Univ Arkansas Med Sci Little Rock AR USA 72205 Little Rock, AR 72205 USA
Titolo Testata:
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
fascicolo: 2, volume: 12, anno: 2001,
pagine: 89 - 98
SICI:
1084-9521(200104)12:2<89:HSPIIA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; HUMAN HEPATOCELLULAR-CARCINOMA; CELL-SURFACE PROTEOGLYCAN; MAMMARY EPITHELIAL-CELLS; FACTOR SCATTER FACTOR; HUMAN-MELANOMA CELLS; SYNDECAN-1 EXPRESSION; MAMMALIAN HEPARANASE; EXTRACELLULAR-MATRIX; TUMOR-METASTASIS;
Keywords:
adhesion; cancer; heparan sulfate proteoglycans; metastasis; motility;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
91
Recensione:
Indirizzi per estratti:
Indirizzo: Sanderson, RD Univ Arkansas Med Sci, Arkansas Canc Res Ctr, Dept Pathol, Slot 517,4301 WMarkham, Little Rock, AR 72205 USA Univ Arkansas Med Sci Slot517,4301 W Markham Little Rock AR USA 72205
Citazione:
R.D. Sanderson, "Heparan sulfate proteoglycans in invasion and metastasis", SEM CELL D, 12(2), 2001, pp. 89-98

Abstract

Because heparan sulfate proteoglycans mediate cell adhesion and control the activities of numerous growth and motility factors, they play a critical tale in regulating the metastatic behavior of tumor cells. Due to their utilitarian nature, heparan sulfate proteoglycans may at times act as inhibitors of cell invasion and at other times as promoters of cell invasion, with their function being determined by their location (cell surface or extracellular matrix), the heparin-binding molecules they associate with, the presence of modifing enzymes (proteases, heparanases) and the precise structuralcharacteristics of the proteoglycan. Also, the tissue type and pathophysiological state of the tumor influence proteogylcan function. This review summarizes our current knowledge of the role heparan sulfate proteoglycans play in regulating tumor cell metastasis, proposes mechanisms of how these molecules function and examines the potential for discovery of new therapeuticapproaches designed to block metastatic cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:14:21