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Titolo:
Impaired associative learning in chronic schizophrenics and their first-degree relatives: A study of latent inhibition and the Kamin blocking effect
Autore:
Serra, AM; Jones, SH; Toone, B; Gray, JA;
Indirizzi:
Inst Psychiat, London SE5 8AF, England Inst Psychiat London England SE5 8AF t Psychiat, London SE5 8AF, England Birch Hill Hosp, Dept Clin Psychol, Laurence Burns Unit, Rochdale OL12 9QB, England Birch Hill Hosp Rochdale England OL12 9QB it, Rochdale OL12 9QB, England
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 2-3, volume: 48, anno: 2001,
pagine: 273 - 289
SICI:
0920-9964(20010330)48:2-3<273:IALICS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRONE NORMAL SUBJECTS; NUCLEUS-ACCUMBENS; SWITCHING MODEL; PREEXPOSURE; AMPHETAMINE; PSYCHOTICISM; DISORDERS; PSYCHOSIS; ABOLITION; DURATION;
Keywords:
associative learning; Kamin blocking effect; latent inhibition; schizophrenia; schizotypy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Gray, JA Inst Psychiat, De Crespigny Pk,Denmark Hill, London SE5 8AF, England Inst Psychiat De Crespigny Pk,Denmark Hill London England SE5 8AF
Citazione:
A.M. Serra et al., "Impaired associative learning in chronic schizophrenics and their first-degree relatives: A study of latent inhibition and the Kamin blocking effect", SCHIZOPHR R, 48(2-3), 2001, pp. 273-289

Abstract

The performance of chronic schizophrenic probands (n = 21), their first-degree schizotypal (22) and non-schizotypal (19) relatives, and normal controls (24), was measured in two associative learning paradigms, latent inhibition and the Kamin blocking effect. These paradigms assess the effects on learning of initial exposure to other learning contingencies. The normal subjects showed latent inhibition (retarded learning of an association between a burst of white noise and a visually displayed counter increment, if the subject had first been pre-exposed to the white noise without any other consequence) and Kamin blocking (retarded learning of an association between two visual stimuli, if the conditioned stimulus was presented simultaneously with a second, already conditioned stimulus). The schizophrenic probands and both the schizotypal and non-schizotypal relatives were severely impairedin basic associative learning, performing much worse than the normal subjects in the control conditions (i.e. those lacking stimulus pre-exposure of any kind) of both the latent inhibition and the Kamin paradigms and also showed a loss of the normal latent inhibition and Kamin blocking effects. Theperformance of the three clinically defined groups was statisitically indistinguishable. These findings contrast with previous reports of the performance of normal subjects classified as schizotypal by questionnaire, who arenot impaired in basic associative learning, and are particularly fast to learn after stimulus pre-exposure. The results question the assumption that high schizotypy, as assessed by questionnaire, is like schizotypy in schizophrenic kin. The severe impairment in basic associative learning in schizophrenic patients and their kin warrants further investigation (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 20/01/20 alle ore 07:38:08