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Titolo:
Outcome in children with fetal mild ventriculomegaly: a case series
Autore:
Gilmore, JH; van Tol, JJ; Streicher, HL; Williamson, K; Cohen, SB; Greenwood, RS; Charles, HC; Kliewer, MA; Whitt, JK; Silva, SG; Hertzberg, BS; Chescheir, NC;
Indirizzi:
Univ N Carolina, Sch Med, Dept Psychiat, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 chiat, Chapel Hill, NC 27599 USA Univ N Carolina, Dept Neurol, Sch Med, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 h Med, Chapel Hill, NC 27599 USA Duke Univ, Ctr Med, Dept Radiol, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Ctr Med, Dept Radiol, Durham, NC 27710 USA Univ N Carolina, Sch Med, Dept Obstet & Gynecol, Chapel Hill, NC 27599 USAUniv N Carolina Chapel Hill NC USA 27599 necol, Chapel Hill, NC 27599 USA
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 2-3, volume: 48, anno: 2001,
pagine: 219 - 226
SICI:
0920-9964(20010330)48:2-3<219:OICWFM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIT HYPERACTIVITY DISORDER; CLINICAL COURSE; KNOCKOUT MICE; IN-UTERO; SCHIZOPHRENIA; BRAIN; ULTRASOUND; INFANTS; AUTISM; RISK;
Keywords:
ultrasound; magnetic resonance imaging; schizophrenia; autism; learning disorder; fetal brain development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Gilmore, JH Univ N Carolina, Sch Med, Dept Psychiat, Chapel Hill, NC 27599USA Univ N Carolina Chapel Hill NC USA 27599 l Hill, NC 27599 USA
Citazione:
J.H. Gilmore et al., "Outcome in children with fetal mild ventriculomegaly: a case series", SCHIZOPHR R, 48(2-3), 2001, pp. 219-226

Abstract

Mild enlargement of the lateral ventricles is associated with schizophrenia and other neurodevelopmental disorders. While it has been hypothesized that ventricle abnormalities associated with neurodevelopmental disorders arise during fetal brain development, there is little direct evidence to support this hypothesis. Using ultrasound, it is possible to image the fetal ventricles in utero, Fetal mild ventriculomegaly (MVM) has been associated with developmental delays in early childhood, though longer-term neurodevelopmental outcome has not been studied. Follow-up of five children (aged 4-9 years) with mild enlargement of the lateral ventricles on prenatal ultrasoundand two unaffected co-twins is reported: one child had attention deficit hyperactivity disorder (ADHD), one had autism, and two had evidence of learning disorders. These cases suggest that the mild enlargement of the lateralventricles associated with these neurodevelopmental disorders arises during fetal brain development and can be detected with prenatal ultrasound. In addition, the presence of mildly enlarged, asymmetric ventricles in two children on prenatal ultrasound and on follow-up MRI at age 6 years indicates that ventricle structure present in utero can persist well into childhood brain development. The study of fetal ventricle development with ultrasound may provide important insights into neurodevelopmental disorders and allow the identification of children at high risk. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 01/06/20 alle ore 02:29:18