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Titolo:
Hypofrontality - a risk-marker related to schizophrenia?
Autore:
Wuebben, Y; Winterer, G;
Indirizzi:
Free Univ Berlin, Dept Psychiat, D-14050 Berlin, Germany Free Univ BerlinBerlin Germany D-14050 sychiat, D-14050 Berlin, Germany NIMH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892NIMH, Bethesda, MD 20892 USA
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 2-3, volume: 48, anno: 2001,
pagine: 207 - 217
SICI:
0920-9964(20010330)48:2-3<207:H-ARRT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; SCHIZOTYPAL PERSONALITY; DEPRESSED-PATIENTS; SPECTRAL-ANALYSIS; MAJOR DEPRESSION; EEG DIFFERENCES; METABOLIC-RATE; PSYCHIATRY; RELATIVES;
Keywords:
cortical hypoactivation; EEG activity; hypofrontality; risk-marker;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Wuebben, Y Free Univ Berlin, Dept Psychiat, Eschenallee 3, D-14050 Berlin,Germany Free Univ Berlin Eschenallee 3 Berlin Germany D-14050 Germany
Citazione:
Y. Wuebben e G. Winterer, "Hypofrontality - a risk-marker related to schizophrenia?", SCHIZOPHR R, 48(2-3), 2001, pp. 207-217

Abstract

In order to better understand whether cortical hypoactivation and hypofrontality is a possible risk marker for schizophrenia, we investigated restingEEG activity in 39 unmedicated schizophrenics and 21 persons with schizotypal personality. Compared to a normal control group, we found an increased,frontally pronounced delta activity in schizophrenic patients, a result that is in accordance with other studies. Subjects with schizotypal personality, who are believed to have an increased risk for schizophrenia, did not show an increase of delta activity. From this result, we concluded that cortical hypoactivation and hypofrontality - defined as an increase of frontally pronounced delta activity during resting EEG - cannot be interpreted as arisk factor for schizophrenia. However, since it is controversial whether subjects with schizotypal personality are at increased risk for schizophrenia, further studies in unaffected family members of schizophrenic patients are needed. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 22/01/20 alle ore 21:40:36