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Titolo:
Temporal lobe volume determined by magnetic resonance imaging in schizotypal personality disorder and schizophrenia
Autore:
Downhill, JE; Buchsbaum, MS; Hazlett, EA; Barth, S; Roitman, SL; Nunn, M; Lekarev, O; Wei, TC; Shihabuddin, L; Mitropoulou, V; Silverman, J; Siever, LJ;
Indirizzi:
CUNY Mt Sinai Sch Med, Dept Psychiat, Neurosci PET Lab, New York, NY 10029USA CUNY Mt Sinai Sch Med New York NY USA 10029 ET Lab, New York, NY 10029USA DVA Med Ctr, Psychiat Serv, Bronx, NY 10468 USA DVA Med Ctr Bronx NY USA 10468 ed Ctr, Psychiat Serv, Bronx, NY 10468 USA
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 2-3, volume: 48, anno: 2001,
pagine: 187 - 199
SICI:
0920-9964(20010330)48:2-3<187:TLVDBM>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; BRAIN VOLUMES; GRAY-MATTER; ABNORMALITIES; PSYCHOPATHOLOGY; PERFORMANCE; METABOLISM; SYMPTOMS; SIZE; AGE;
Keywords:
corpus callosum; gray matter; superior temporal gyrus; white matter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Downhill, JE CUNY Mt Sinai Sch Med, Dept Psychiat, Neurosci PET Lab, Box 1505,1 GustaveL Levy Pl, New York, NY 10029 USA CUNY Mt Sinai Sch Med Box 1505,1 Gustave L Levy Pl New York NY USA 10029
Citazione:
J.E. Downhill et al., "Temporal lobe volume determined by magnetic resonance imaging in schizotypal personality disorder and schizophrenia", SCHIZOPHR R, 48(2-3), 2001, pp. 187-199

Abstract

The volumes of the whole temporal lobe, the superior temporal gyrus and the corpus callosum were measured on magnetic resonance images from 13 patients with schizotypal personality disorder (SPD), 27 patients with schizophrenia, and 31 age- and sex-matched controls. Temporal lobe structures were traced on consecutive 1.2 mm thick SPGR images. Both patient groups had smaller temporal lobes than normal volunteers, a difference that was more markedfor the area outside the superior temporal gyrus than for the STG. Correcting for brain volume diminished differences between normal subjects and schizophrenia patients, but the differences between normal subjects and SPD patients remained. Normal volunteers and SPD patients showed significant correlations between the sagittal section area of the posterior portion of the corpus callosum, which carries temporal interhemispheric connections, and the white matter volume of the temporal lobe. While the sample size is modest, taken together, these results suggest that the psychopathological symptoms of SPD may be related to temporal gray matter loss with relatively intact white matter connectivity, while the cognitive and psychotic symptoms of schizophrenia may be related to temporal gray loss combined with disruptionof normal patterns of white matter development. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:08:12