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Titolo:
Pump prime aprotinin fails to limit proinflammatory cytokine release aftercoronary artery bypass surgery
Autore:
Wei, MX; Kuukasjarvi, P; Laurikka, J; Pehkonen, E; Kaukinen, S; Laine, S; Tarkka, M;
Indirizzi:
Tampere Univ Hosp, Div Cardiothorac Surg, FI-33521 Tampere, Finland Tampere Univ Hosp Tampere Finland FI-33521 rg, FI-33521 Tampere, Finland Tampere Univ Hosp, Dept Anesthesia & Intens Care, FI-33521 Tampere, Finland Tampere Univ Hosp Tampere Finland FI-33521 re, FI-33521 Tampere, Finland Tampere Univ Hosp, Dept Clin Chem, FI-33521 Tampere, Finland Tampere Univ Hosp Tampere Finland FI-33521 em, FI-33521 Tampere, Finland
Titolo Testata:
SCANDINAVIAN CARDIOVASCULAR JOURNAL
fascicolo: 1, volume: 35, anno: 2001,
pagine: 50 - 54
SICI:
1401-7431(200102)35:1<50:PPAFTL>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOPULMONARY BYPASS; CARDIAC OPERATIONS; HEMOSTASIS; ISCHEMIA;
Keywords:
aprotinin; coronary artery bypass grafting; cytokines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Tarkka, M Tampere Univ Hosp, Div Cardiothorac Surg, POB 2000, FI-33521 Tampere, Finland Tampere Univ Hosp POB 2000 Tampere Finland FI-33521 re, Finland
Citazione:
M.X. Wei et al., "Pump prime aprotinin fails to limit proinflammatory cytokine release aftercoronary artery bypass surgery", SC CARDIOVA, 35(1), 2001, pp. 50-54

Abstract

Background-The purpose of this study was to establish whether pump prime aprotinin could limit the cytokine responses in patients undergoing electivecoronary artery bypass surgery. Methods-Twenty-one patients admitted for first-time elective coronary artery bypass surgery were randomized into control or aprotinin groups. Patients in the aprotinin group received 280 mg aprotinin in the pump prime. Leukocyte count, creatine kinase cardiac isoenzyme (CK-MB), cytokine production and postoperative blood loss were analyzed perioperatively and compared with preoperative values. Results-The peak level of leukocyte count was lower in the aprotinin groupthan in controls (9.3 +/- 0.58 vs 11.2 +/- 0.68 x 10(9)/L, p = 0.01). Interleukin (IL)-6 and IL-8 did not differ significantly between the groups throughout: the study period. Plasma IL-10 levels were higher in the controls than in the aprotinin group at 5 min (49.6 +/- 24.9 vs 8.13 +/- 2.8 p g/ml,p = 0.01) after reperfusion. Conclusion-Pump prime aprotinin fails to limit proinflammatory cytokine response in circulating blood.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:13:27