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Titolo:
Inhaled nitric oxide effectively decreases right heart afterload followingright heart infarct in pigs
Autore:
Spalding, MB; Ala-Kokko, TI; Kiviluoma, K; Alahuhta, S; Juvonen, T;
Indirizzi:
Univ Hosp Oulu, Dept Anesthesiol, FI-90220 Oulu, Finland Univ Hosp Oulu Oulu Finland FI-90220 Anesthesiol, FI-90220 Oulu, Finland Univ Hosp Oulu, Dept Surg, FI--90220 Oulu, Finland Univ Hosp Oulu Oulu Finland FI--90220 Dept Surg, FI--90220 Oulu, Finland
Titolo Testata:
SCANDINAVIAN CARDIOVASCULAR JOURNAL
fascicolo: 1, volume: 35, anno: 2001,
pagine: 45 - 49
SICI:
1401-7431(200102)35:1<45:INOEDR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY VASCULAR-RESISTANCE; ONE-LUNG VENTILATION; CARDIAC-SURGERY; OXYGENATION; FAILURE; INHALATION;
Keywords:
experimental animals; nitric oxide; right heart failure; volume loading;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Spalding, MB Univ Hosp Oulu, Dept Anesthesiol, Kajaanintie 50, FI-90220 Oulu, Finland Univ Hosp Oulu Kajaanintie 50 Oulu Finland FI-90220 Finland
Citazione:
M.B. Spalding et al., "Inhaled nitric oxide effectively decreases right heart afterload followingright heart infarct in pigs", SC CARDIOVA, 35(1), 2001, pp. 45-49

Abstract

Objective-To test the hypothesis that nitric oxide is beneficial in acute right heart failure after right ventricle infarct, Right ventricle infarct results in a decrease in right heart function with a subsequent reduction in ejection fraction and cardiac index. The pulmonary circulation is compromised as the right ventricle weakens, and the resulting stasis and further weakening of the ventricle present clinically as an increase in right heart afterload. Pulmonary vasodilation should ease these hemodynamic symptoms ofright heart infarct. Design-Ten 3-4-month-old pigs were chosen as experimental animals. All animals were cannulated, a sternotomy was performed and branches of the right main coronary were ligated to cause infarct of the right ventricle, After a4-h stabilization period, all animals received fluid preload with a dextrose-based solution after which control hemodynamic measurements were recorded. Treatment with inhaled nitric oxide was begun at progressive concentrations and hemodynamic measurements recorded at 30-min intervals. Results-Nitric oxide treatment significantly reduced right heart afterload, which was also apparent as a reduction in left heart preload. A significant deterioration was observed in cardiac output as well as in left and right ventricle stroke work indices. Conclusion-The use of nitric oxide in this model of right heart infarct inpreviously healthy young swine effected a decrease in both right heart afterload and left heart preload, with an overall deterioration in global hemodynamics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 14:26:30