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Titolo:
Effects of transmyocardial revascularization on myocardial perfusion and systolic function assessed by nuclear and magnetic resonance imaging methods
Autore:
Aaberge, L; Rootwelt, K; Smith, HJ; Nordstrand, K; Forfang, K;
Indirizzi:
Univ Oslo, Natl Hosp, Dept Cardiol, Oslo, Norway Univ Oslo Oslo NorwayUniv Oslo, Natl Hosp, Dept Cardiol, Oslo, Norway Univ Oslo, Natl Hosp, Dept Clin Chem, Nucl Med Sect, Oslo, Norway Univ Oslo Oslo Norway Hosp, Dept Clin Chem, Nucl Med Sect, Oslo, Norway Univ Oslo, Natl Hosp, Dept Radiol, Oslo, Norway Univ Oslo Oslo NorwayUniv Oslo, Natl Hosp, Dept Radiol, Oslo, Norway Feiring Heart Clin, Feiring, Norway Feiring Heart Clin Feiring NorwayFeiring Heart Clin, Feiring, Norway
Titolo Testata:
SCANDINAVIAN CARDIOVASCULAR JOURNAL
fascicolo: 1, volume: 35, anno: 2001,
pagine: 8 - 13
SICI:
1401-7431(200102)35:1<8:EOTROM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
REFRACTORY ANGINA-PECTORIS; LASER REVASCULARIZATION; RANDOMIZED TRIAL; MEDICAL THERAPY; ADVERSE EVENTS; DISEASE; HOLMIUM; YAG;
Keywords:
laser; MRI; MUGA; myocardial function; myocardial perfusion; QGSPECT; SPECT; stable angina;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Aaberge, L Feiringklin, N-2093 Feiring, Norway Feiringklin Feiring Norway N-2093 lin, N-2093 Feiring, Norway
Citazione:
L. Aaberge et al., "Effects of transmyocardial revascularization on myocardial perfusion and systolic function assessed by nuclear and magnetic resonance imaging methods", SC CARDIOVA, 35(1), 2001, pp. 8-13

Abstract

Objective-There is no obvious explanation, except placebo, to the symptomatic effect of transmyocardial laser revascularization (TMR) in patients with refractory angina. Whether TMR improves myocardial perfusion or relieves symptoms without altering cardiac function is not clarified. Methods-One hundred patients with refractory angina were randomized 1:1 toTMR (CO2 laser) and medical treatment, or medical treatment alone. Technetium 99m (Tc-99m)-tetrofosmin myocardial perfusion tomography (SPECT), quantitative myocardial perfusion gated SPECT (QGSPECT), technetium 99m (Tc-99m)multiple gated acquisition radionuclide ventriculografi (MUGA) and cine-magnetic resonance imaging (cine-MRI) were performed at baseline and after 3 and 12 months. Results-Following TM:R, a slight reduction in left ventricular ejection fraction (LVEF) (p < 0.05) was observed (MUGA and QGSPECT) compared to baseline. Inclusion of incomplete studies (QGSPECT) revealed a significant reduction in LVEF and increase in left ventricular end-diastolic volume (LVEDV) (p < 0.05) compared to a control group. Otherwise, no between-group comparisons showed statistically significant differences. Conclusion-TMR did not improve myocardial perfusion, but led to a reduction in LVEF and increase in LVEDV, however not significantly different from the control group.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:51:57