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Titolo:
Effect of leptin on insulin sensitivity in the Otsuka Long-Evans TokushimaFatty rat
Autore:
Mizuno, A; Murakami, T; Doi, T; Shima, K;
Indirizzi:
Univ Tokushima, Sch Med, Dept Lab Med, Tokushima 7708503, Japan Univ Tokushima Tokushima Japan 7708503 Lab Med, Tokushima 7708503, Japan
Titolo Testata:
REGULATORY PEPTIDES
fascicolo: 1, volume: 99, anno: 2001,
pagine: 41 - 44
SICI:
0167-0115(20010505)99:1<41:EOLOIS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBESE GENE; GLUCOSE-METABOLISM; INDIVIDUAL TISSUES; SKELETAL-MUSCLE; DOSE-RESPONSE; INVIVO; MICE; INFUSION; STRAIN; OB/OB;
Keywords:
OLETF; obese; diabetes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Murakami, T Univ Tokushima, Sch Med, Dept Lab Med, Kuramotocho 3 Chome, Tokushima 7708503, Japan Univ Tokushima Kuramotocho 3 Chome Tokushima Japan 7708503 an
Citazione:
A. Mizuno et al., "Effect of leptin on insulin sensitivity in the Otsuka Long-Evans TokushimaFatty rat", REGUL PEPT, 99(1), 2001, pp. 41-44

Abstract

Leptin has been proposed to be a sensor of energy storage in adipose tissues, and is capable of mediating a feedback signal to the hypothalamus, which is involved in the regulation of energy homeostasis and body weight. In order to investigate the issue of whether resistance to the activity of leptin on insulin sensitivity is observed in young Otsuka Long-Evans Tokushima Fatty (OLETF) rats at 8 weeks of age, leptin (50 nmol/kg/h) was administered intravenously for 16 h to OLETF and Long-Evans Tokushima Otsuka (LETO) (lean controls) rats, followed by a measurement of insulin-stimulated glucoseuptake in hindlimb muscles during hyperinsulinemic euglycemic clamp technique. In the case of LETO rats, the administration of leptin significantly decreased plasma insulin levels prior to the clamp test, but did not change plasma glucose levels. Furthermore, leptin led to an increase in insulin-stimulated glucose uptake in hindlimb muscles. However, in the case of OLETF rats, leptin administration changed neither plasma insulin levels nor insulin-stimulated glucose uptake. These data demonstrate that OLETF rats at 8 weeks of age have already become resistant to high concentration of peripheral leptin. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 04:07:02