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Titolo:
Inhibition of immunologic and nonimmunologic stimulation-mediated anaphylactic reactions by water extract of white eggplant (Solanum melongena)
Autore:
Lee, YM; Jeong, HJ; Na, HJ; Ku, JY; Kim, DK; Goo-Moon; Chae, HJ; Kim, HR; Baek, SH; Kim, HM;
Indirizzi:
Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Ctr Oriental Med Sci, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea NIAID, Lab Allerg Dis, NIH, Rockville, MD 20852 USA NIAID Rockville MD USA 20852 Lab Allerg Dis, NIH, Rockville, MD 20852 USA Wonkwang Univ, Coll Oriental Med, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Sch Dent, Dept Dent Pharmacol, Iksan 570749, Chonbuk, SouthKorea Wonkwang Univ Iksan Chonbuk South Korea 570749 70749, Chonbuk, SouthKorea Wonkwang Univ, Profess Grad Sch Oriental Med, Dept Nat Prod, Iksan 570749,Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 70749,Chonbuk, South Korea
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 4, volume: 43, anno: 2001,
pagine: 405 - 409
SICI:
1043-6618(200104)43:4<405:IOIANS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERITONEAL MAST-CELLS; TUMOR-NECROSIS-FACTOR; HISTAMINE-RELEASE; HIGH-AFFINITY; SUBSTANCE-P; RECEPTOR; IGE; RAT; COMPOUND-48/80; RECRUITMENT;
Keywords:
Solanum melongena; anaphylactic reactions; mast cells; histamine; tumor necrosis factor-alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, HM Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 onbuk, South Korea
Citazione:
Y.M. Lee et al., "Inhibition of immunologic and nonimmunologic stimulation-mediated anaphylactic reactions by water extract of white eggplant (Solanum melongena)", PHARMAC RES, 43(4), 2001, pp. 405-409

Abstract

We investigated the effect of water extract of Solanum melongena (SMWE) onimmunologic and nonimmunologic stimulation-mediated anaphylactic reactions. Nonimmunologic anaphylactic reaction was induced by compound 48/80 injection. Oral administration of SMWE (I g kg(-1)) completely inhibited compound48/80-induced anaphylactic reaction. Immunologic anaphylactic reaction wasgenerated by sensitizing the skin with anti-dinitrophenyl (DNP) IgE followed 48 h later with an injection of antigen, Oral administration of SMWE (0.01-1 g kg(-1)) significantly inhibited passive cutaneous anaphylactic reaction activated by anti-DNP IgE to between 83.10 +/- 1.67% and 70.17 +/- 2.17%. SMWE (0.01-1 mg ml(-1)) also inhibited histamine release activated by compound 48/80 to between 93 +/- 2.65 and 70 +/- 1.50%. Moreover, SMWE (0.01-1 mg ml(-1)) had a significant inhibitory effect on IgE-induced tumor necrosis factor (TNF)-alpha, secretion from rat peritoneal mast cells. These results indicate that SMWE inhibits immunologic and nonimmunologic stimulation-mediated anaphylactic reactions and TNF-alpha secretion from mast cells. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 05:07:02