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Titolo:
The influence of simvastatin on lipase and cholesterol esterase activity in the serum of men with coronary heart disease
Autore:
Piorunska-Stolzmann, M; Piorunska-Mikolajczak, A;
Indirizzi:
Karol Marcinkowski Univ Med Sci, Dept Chem & Clin Biochem, PL-60780 Poznan, Poland Karol Marcinkowski Univ Med Sci Poznan Poland PL-60780 80 Poznan, Poland
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 4, volume: 43, anno: 2001,
pagine: 359 - 362
SICI:
1043-6618(200104)43:4<359:TIOSOL>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
COA REDUCTASE INHIBITORS; LIPOPROTEIN METABOLISM; PLASMA-CHOLESTEROL; STATINS; HYPERTRIGLYCERIDEMIA; ATHEROSCLEROSIS;
Keywords:
lipase; cholesterol esterase; simvastatin; serum; CHD men;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Piorunska-Stolzmann, M Karol Marcinkowski Univ Med Sci, Dept Chem & Clin Biochem, Grunwaldzka 6, PL-60780 Poznan, Poland Karol Marcinkowski Univ Med Sci Grunwaldzka 6 Poznan Poland PL-60780
Citazione:
M. Piorunska-Stolzmann e A. Piorunska-Mikolajczak, "The influence of simvastatin on lipase and cholesterol esterase activity in the serum of men with coronary heart disease", PHARMAC RES, 43(4), 2001, pp. 359-362

Abstract

Several studies have demonstrated that any beneficial effects of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins), of which simvastatin (Merck Sharp & Dohme) is an example, on coronary events are linked to their hypocholesterolemic properties. The in vivo effects of simvastatin treatment on lipase (GEH = glycerol ester hydrolase) and cholesterol esterase (CEase) activity in the serum of men with coronary heart disease (CHD) were examined. CEH and CEase activity in the serum olf men with CHD, before simvastatin treatment, was lower than in the control subjects. Inour study we have provided evidence that simvastatin increases GEH activity in a time-dependent manner, but has no effect on CEase activity. This suggests that simvastatin can directly affect acylglycerol metabolism by an increase in GEH activity and may therefore be suitable for the treatment of combined lipoprotein disorders characterized by elevation of triacylglycerols. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:34:10