Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Acute trazodone and quipazine treatment attenuates apomorphine-induced aggressive behaviour in male rats without major impact on emotional behaviour or monoamine content post mortem
Autore:
Rudissaar, R; Pruus, K; Vaarmann, A; Pannell, P; Skrebuhhova-Malmros, T; Allikmets, L; Matto, V;
Indirizzi:
Univ Tartu, Dept Pharmacol, EE-50090 Tartu, Estonia Univ Tartu Tartu Estonia EE-50090 ept Pharmacol, EE-50090 Tartu, Estonia
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 4, volume: 43, anno: 2001,
pagine: 349 - 358
SICI:
1043-6618(200104)43:4<349:ATAQTA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
REUPTAKE INHIBITORS; ANIMAL-MODELS; RECEPTORS; ANXIETY; DRUGS; MICE; RODENTS; FLUOXETINE; IMIPRAMINE; WITHDRAWAL;
Keywords:
apomorphine; aggressive behaviour; trazodone; quipazine; monoamine content; HPLC-ECD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Matto, V Univ Tartu, Dept Pharmacol, Ulikooli St 18, EE-50090 Tartu, Estonia Univ Tartu Ulikooli St 18 Tartu Estonia EE-50090 Tartu, Estonia
Citazione:
R. Rudissaar et al., "Acute trazodone and quipazine treatment attenuates apomorphine-induced aggressive behaviour in male rats without major impact on emotional behaviour or monoamine content post mortem", PHARMAC RES, 43(4), 2001, pp. 349-358

Abstract

We have studied the effect of acute trazodone (3-20 mg kg(-1)) and quipazine (1-3 mg kg(-1)) treatment on the apomorphine-induced (1 nag kg(-1), oncedaily over 2 weeks) aggressive behaviour in male Wistar rats. All doses oftrazodone and quipazine tested attenuated the aggressiveness as evidenced by the abolished intensity of aggressive behaviour and increased time of latency before the first attack. The acute trazodone (3-10 mg kg(-1)) or quipazine (1-3 mg kg(-1)) treatment had no or only a minor effect on rat behaviour in the elevated plus-maze, open held, and forced swimming test. Concomitant apomorphine (1 mg kg(-1)) plus trazodone (3 mg kg(-1)), but not apomorphine (1 mg kg(-1)) plus quipazine (1 mg kg(-1)), treatment slowed the development of aggressive behaviour. Repeated apomorphine treatment moderately reduced the dopamine post mortem and increased the DOPAC and HVA contents in striatum. Other monoamines or their metabolites were unchanged. Neither trazodone and quipazine treatment nor forced swimming stress induced any changes in the monoamine contents. Tn conclusion, our results indicate that acute trazodone and quipazine treatment attenuates the apomorphine-induced aggressive behaviour in male rats, but this phenomenon cannot be implicated in the changes in emotional and motivational behaviour, or in changes of monoamine content post mortem. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:53:57