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Titolo:
Inhibition of baclofen on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity
Autore:
Woo, SH; Kim, HS; Yun, JS; Lee, MK; Oh, KW; Seong, YH; Oh, SK; Jang, CG;
Indirizzi:
Chungbuk Natl Univ, Coll Pharm, Dept Pharmacol, Cheongju 361763, South Korea Chungbuk Natl Univ Cheongju South Korea 361763 ongju 361763, South Korea Chungbuk Natl Univ, Coll Vet Med, Cheongju 361763, South Korea Chungbuk Natl Univ Cheongju South Korea 361763 ongju 361763, South Korea Ewha Womans Univ, Coll Med, Seoul 158710, South Korea Ewha Womans Univ Seoul South Korea 158710 Med, Seoul 158710, South Korea Hallym Univ, Inst Nat Med, Chunchon 200702, South Korea Hallym Univ Chunchon South Korea 200702 ed, Chunchon 200702, South Korea
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 4, volume: 43, anno: 2001,
pagine: 335 - 340
SICI:
1043-6618(200104)43:4<335:IOBOMH>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED PLACE PREFERENCE; VENTRAL TEGMENTAL AREA; IN-VIVO MICRODIALYSIS; FREELY MOVING RAT; LOCOMOTOR-ACTIVITY; NUCLEUS-ACCUMBENS; GABAERGIC MODULATION; SUPER-SENSITIVITY; RELEASE; COCAINE;
Keywords:
baclofen; morphine; hyperactivity; reverse tolerance; postsynaptic dopamine receptor supersensitivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, HS Chungbuk Natl Univ, Coll Pharm, Dept Pharmacol, Cheongju 361763, South Korea Chungbuk Natl Univ Cheongju South Korea 361763 1763, South Korea
Citazione:
S.H. Woo et al., "Inhibition of baclofen on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity", PHARMAC RES, 43(4), 2001, pp. 335-340

Abstract

The effects of baclofen on the development of reverse tolerance and postsynaptic dopamine receptor supersensitivity induced by morphine were examinedin mice. A single administration of morphine induced hyperactivity and themorphine-induced hyperactivity was inhibited dose dependently by the administration of a GABAB receptor agonist, baclofen (1.25, 2.5 and 5 mg kg(-1),i.p.). Daily repeated administration of morphine developed reverse tolerance to the hyperactivity of morphine. The concomitant administration of baclofen inhibited the morphine-induced hyperactivity and the baclofen administration prior to and during the chronic administration of morphine in mice inhibited the development of reverse tolerance to the hyperactivity of morphine (10 mg kg(-1), s.c.). Postsynaptic dopamine receptor supersensitivity was also developed in reverse-tolerant mice that had received the same morphine. The development of postsynaptic dopamine receptor supersensitivity wasevidenced by the enhanced ambulatory activity of apomorphine (2 mg kg(-1),s.c.). Baclofen also inhibited the development of postsynaptic dopamine receptor supersensitivity induced by the chronic administration of morphine. These results suggest that the hyperactivity. reverse tolerance and postsynaptic dopamine receptor supersensitivity induced by morphine may be modulated via the activation of GABA(B) receptors induced by baclofen. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 02:29:35