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Titolo:
Establishment and characterization of an oral melanoma cell line (ME)
Autore:
Chang, KW; Lin, SC; Chao, SY; Kwan, PC; Chiu, CP; Wong, YK;
Indirizzi:
Natl Yang Ming Univ, Inst Oral Biol, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 Inst Oral Biol, Taipei 112, Taiwan Natl Yang Ming Univ, Fac Dent, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 Univ, Fac Dent, Taipei 112, Taiwan Taichung Vet Gen Hosp, Dept Dent, Div Oral & Maxillofacial Surg, Taichung 407, Taiwan Taichung Vet Gen Hosp Taichung Taiwan 407 ial Surg, Taichung 407, Taiwan Taichung Vet Gen Hosp, Dept Pathol, Taichung 407, Taiwan Taichung Vet Gen Hosp Taichung Taiwan 407 t Pathol, Taichung 407, Taiwan
Titolo Testata:
ORAL ONCOLOGY
fascicolo: 3, volume: 37, anno: 2001,
pagine: 301 - 307
SICI:
1368-8375(200104)37:3<301:EACOAO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARATIVE GENOMIC HYBRIDIZATION; MALIGNANT-MELANOMA; CUTANEOUS MELANOMA; MUCOSAL MELANOMAS; EXPRESSION; CARCINOMAS; P53; MUTATIONS; TUMORS; RISK;
Keywords:
cell line; melanoma; oral cavity; p16/MTS1 gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Wong, YK Natl Yang Ming Univ, Inst Oral Biol, Taipei 112, Taiwan Natl YangMing Univ Taipei Taiwan 112 Biol, Taipei 112, Taiwan
Citazione:
K.W. Chang et al., "Establishment and characterization of an oral melanoma cell line (ME)", ORAL ONCOL, 37(3), 2001, pp. 301-307

Abstract

A new cell line, ME, has been established from a melanoma of the palatal mucosa. The cultured monolayer of cells was fusiform and melanin-producing. The cells were highly tumorigenic and metastatic in nude mice. The xenographic tumors resembled the original tumor in morphology, melanin production, and the expression of S-100 and HMB-45 antigens. The metaphase karyotype ofME indicated multiple aberrations of chromosomes 2, 3, 5, 7-11, 13, 19, 21and X. A homozygous loss of the p16/MTS1 gene during the establishment of ME correlated with karyotypic evidence of chromosome 9 abnormalities. Absence of nm23 protein expression and elevated expression of CD44 protein (indicative of melastatic phenotypes) were demonstrated in primary and xenographic tumors. ME cells could be valuable in developing novel therapeutic strategies for oral melanoma. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:26:55