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Titolo:
Lack of association between p53 expression and betel nut chewing in oral cancers front Thailand
Autore:
Thongsuksai, P; Boonyaphiphat, P;
Indirizzi:
Prince Songkla Univ, Fac Med, Dept Pathol, Songkhla 90110, Thailand PrinceSongkla Univ Songkhla Thailand 90110 ol, Songkhla 90110, Thailand
Titolo Testata:
ORAL ONCOLOGY
fascicolo: 3, volume: 37, anno: 2001,
pagine: 276 - 281
SICI:
1368-8375(200104)37:3<276:LOABPE>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; PROTEIN EXPRESSION; CIGARETTE-SMOKING; GENE-MUTATIONS; NECK-CANCER; HEAD; TOBACCO; ALCOHOL; OVEREXPRESSION; TAIWAN;
Keywords:
p53; expression; oral cancers; betel chewing; tumor suppressor gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Thongsuksai, P Prince Songkla Univ, Fac Med, Dept Pathol, Songkhla 90110, Thailand Prince Songkla Univ Songkhla Thailand 90110 110, Thailand
Citazione:
P. Thongsuksai e P. Boonyaphiphat, "Lack of association between p53 expression and betel nut chewing in oral cancers front Thailand", ORAL ONCOL, 37(3), 2001, pp. 276-281

Abstract

To elucidate whether betel-associated oral squamous cell carcinoma is associated with p53 protein expression, tumor samples from 156 patients with detailed histories of exposures were investigated immunohistochemically usingCMI antibody. The expression of p53 (> 10% positive cells) was found in 38.5% of the cases. The frequency of expression in betel chewers alone and betel chewer with tobacco use were 37.9% (11/29) and 25% (9/36), respectively, whereas that in betel chewers with smoking/drinking it was 47.2%(17/36) and in smokers or drinkers without chewing was 42.0% (21/50). However, the differences were not statistically significant. Multivariate analysis also revealed with the no independent association of betel chewing with p53 expression (odds ratio [OR] 1.81, 95% confidence interval 0.50-6.49), whereas alcohol drinking and smokeless tobacco use were significant (OR 7.58, 2.01-28.53 and 0.39, 0.16-0.98, respectively). These results suggested that betel chewing with or without smokeless tobacco use may not induce oral cancers via a p53-dependent pathway. However, since this is an immunohistochemical study, further molecular analysis is needed. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 08:57:20