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Titolo:
Gene expression of differentiation-specific keratins in oral epithelial dysplasia and squamous cell carcinoma
Autore:
Bloor, BK; Seddon, SV; Morgan, PR;
Indirizzi:
Guys Kings & St Thomas Dent Inst, Dept Oral Med & Pathol, London SE1 9RT, England Guys Kings & St Thomas Dent Inst London England SE1 9RT SE1 9RT, England
Titolo Testata:
ORAL ONCOLOGY
fascicolo: 3, volume: 37, anno: 2001,
pagine: 251 - 261
SICI:
1368-8375(200104)37:3<251:GEODKI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CERVICAL INTRAEPITHELIAL NEOPLASIA; HUMAN ESOPHAGEAL EPITHELIUM; IN-SITU HYBRIDIZATION; CYTOKERATIN EXPRESSION; MONOCLONAL-ANTIBODIES; LICHEN-PLANUS; MESSENGER-RNA; MUCOSA; TUMORS; PATTERNS;
Keywords:
gene expression; differentiation-specific keratins; K4; K13; K1; K10; in situ hybridization; immunohistochemistry; oral epithelial dysplasia; oral squamous cell carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Morgan, PR Guys Kings & St Thomas Dent Inst, Dept Oral Med & Pathol, London SE1 9RT, England Guys Kings & St Thomas Dent Inst London England SE1 9RT gland
Citazione:
B.K. Bloor et al., "Gene expression of differentiation-specific keratins in oral epithelial dysplasia and squamous cell carcinoma", ORAL ONCOL, 37(3), 2001, pp. 251-261

Abstract

The aim of the study was to investigate the differentiation-specific keratins (K4, K13, K1 and K10) in oral epithelial dysplasia and squamous cell carcinoma (SCC). Alterations in keratin gene expression were determined by insitu hybridization using S-35-labeled riboprobes and immunohistochemistry with monoclonal antibodies. In mild dysplasia, both sets of differentiationkeratins were expressed in the same group of cells but in moderate lesions, expression of K4 and K13 was reduced in the presence of enhanced K1 and K10 synthesis. In severe dysplasia, neither mRNAs nor proteins were detected. In tumor islands of well and moderately differentiated SCCs, the K4/K13 complex was co-expressed with K1/K10, but in poorly differentiated carcinomas, differentiation keratins were absent. Consequently, mild oral epithelialdysplasia and well differentiated SCC retain an essentially normal patternof keratin gene expression and hence epithelial differentiation while in severe dysplasia and poorly differentiated SCC keratin gene expression reflects the gross changes in epithelial differentiation and maturation. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:23:57