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Titolo:
Overexpression of BMP-2/4,-5 and BMPR-IA associated with malignancy of oral epithelium
Autore:
Jin, Y; Tipoe, GL; Liong, EC; Lau, TYH; Fung, PCW; Leung, KM;
Indirizzi:
Univ Hong Kong, Fac Med, Dept Anat, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Peoples R China at, Hong Kong, Peoples R China Univ Hong Kong, Dept Biochem, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Hong Kong Polytech Univ, Dept Optometry & Radiog, Hong Kong, Hong Kong, Peoples R China Hong Kong Polytech Univ Hong Kong Hong Kong Peoples R Chinaples R China Univ Hong Kong, Dept Med, Div Med Phys, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China
Titolo Testata:
ORAL ONCOLOGY
fascicolo: 3, volume: 37, anno: 2001,
pagine: 225 - 233
SICI:
1368-8375(200104)37:3<225:OOBABA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE MORPHOGENETIC PROTEIN-6; PROSTATE-CANCER CELLS; PLEOMORPHIC ADENOMA; MESSENGER-RNA; EXPRESSION; LUNG; DIFFERENTIATION; BENIGN; KIDNEY; PLAYS;
Keywords:
BMPs; receptor; epithelium; metastasis; oral; malignant; expression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Tipoe, GL Univ Hong Kong, Fac Med, Dept Anat, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Peoples R China ong, Peoples R China
Citazione:
Y. Jin et al., "Overexpression of BMP-2/4,-5 and BMPR-IA associated with malignancy of oral epithelium", ORAL ONCOL, 37(3), 2001, pp. 225-233

Abstract

The aim of the present study was to determine the relationships between bone morphogenetic proteins (BMPs), BMP receptor type IA and carcinogenesis of oral epithelium. A retrospective study was performed on material obtainedfrom oral mucosa, including nine cases of normal mucosa (NB), eight cases of nonspecific chronic inflammation (NCI), seven cases of hyperkeratosis (HK), five cases of squamous cell papilloma (SCP), 29 cases of squamous cell carcinoma (SCC) with various grades of differentiation and 10 cases of epithelium adjacent to carcinoma (EAC). Six cases of NE from hard palate (NHP) were chosen as a control group. The benign groups consisted of NCI, KK and SCP. The antibodies against BMP-2/4, -5, receptor BMPR-IA and purified bovine BMP (bBMP-McAb) were utilised using an immunocytochemical method. The results demonstrated that the immunostaining of BMP-2/4, BMP-5, BMPR-IA and bBMP-McAb was weak and not consistent in normal and benign groups. The immunoreactivity level was independent of the clinical and pathological grading of SCC. All cases of SCC showed positive staining for BMP-2/4, BMP-5, BMPR-IA and bBMP-McAb except for three cases and one case of SCC which negatively stained for BMP 2/4 and BMP-5, respectively. The staining intensity and proportion of the positively stained cells were markedly increased in SCC when compared with that of the normal and benign groups except for EAC. The metastatic carcinoma cells in lymph nodes were strongly and positively stained for BMP-2/4 and BMP-5 when compared with the primary lesions. Our results indicate that there was an overexpression of BMP-2/4, BMP-5, bBMP-McAb and BMPR-IA in the high-risk premalignant and malignant lesions of oral epithelium. Our findings suggest that BMP-2/4 and BMP-5 but not BMPR-IA might beinvolved in the metastasis of oral carcinoma cells. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 02:07:11