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Titolo:
Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I
Autore:
Iwanaga, R; Ohtani, K; Hayashi, T; Nakamura, M;
Indirizzi:
Tokyo Med & Dent Univ, Human Gene Sci Ctr, Bunkyo Ku, Tokyo 1138510, JapanTokyo Med & Dent Univ Tokyo Japan 1138510 unkyo Ku, Tokyo 1138510, Japan
Titolo Testata:
ONCOGENE
fascicolo: 17, volume: 20, anno: 2001,
pagine: 2055 - 2067
SICI:
0950-9232(20010419)20:17<2055:MMOCCP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTIONAL ACTIVATOR; RETINOBLASTOMA PROTEIN; HTLV-I; S-PHASE; E2F; EXPRESSION; FAMILY; LINE; ACCUMULATION; LYMPHOCYTES;
Keywords:
cell cycle; E2F; HTLV-I; NF-kappa B; tax; cyclin D2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Ohtani, K Tokyo Med & Dent Univ, Human Gene Sci Ctr, Bunkyo Ku, 1-4-45 Yushima, Tokyo 1138510, Japan Tokyo Med & Dent Univ 1-4-45 Yushima Tokyo Japan 1138510 Japan
Citazione:
R. Iwanaga et al., "Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I", ONCOGENE, 20(17), 2001, pp. 2055-2067

Abstract

The trans-activator protein Tax of human T-cell leukemia virus type I(HTLV-I) plays an important role in the development of adult T-cell leukemia through, at least in part, its ability to stimulate cell growth. We previouslyreported that Tax induced cell cycle progression from G0/G1 phase to S andG2/M phases in human T-cell line Kit 225 cells. To elucidate molecular mechanism of Tax-induced cell cycle progression, we systematically examined the effects of Tax on biochemical events associated with cell cycle progression, Introduction of Tax into resting Kit 225 cells induced activation of the G1/S transition regulation cascade consisting of activation of cyclin dependent kinase 2 (CDK2) and CDK4, phosphorylation of the Rb family proteins and an increase in free E2F, The kinase activation was found to result fromTax-induced expression of genes for cell cycle regulatory molecules including cyclin D2, cyclin E, E2F1, CDK2, CDK4 and CDK6, and Tax-induced reduction of CDK inhibitors p19(INK4d) and p27(Kip1), These modulations by Tax always paralleled the ability of Tax to activate the NF-kappaB transcription pathway. These results indicate the important role of Tax-mediated trans-activation of the genes for cell cycle regulatory molecules in Tax-induced cell cycle progression.

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Documento generato il 30/03/20 alle ore 09:03:48