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Titolo:
Effect of moderate hypothermia on experimental severe subarachnoid hemorrhage, as evaluated by apparent diffusion coefficient changes
Autore:
Piepgras, A; Elste, V; Frietsch, T; Schmiedek, P; Reith, W; Schilling, L;
Indirizzi:
Univ Heidelberg, Dept Neurosurg, Fac Clin Med Mannheim, Heidelberg, Germany Univ Heidelberg Heidelberg Germany in Med Mannheim, Heidelberg, Germany Univ Heidelberg, Dept Neuroradiol, Heidelberg, Germany Univ Heidelberg Heidelberg Germany ept Neuroradiol, Heidelberg, Germany
Titolo Testata:
NEUROSURGERY
fascicolo: 5, volume: 48, anno: 2001,
pagine: 1128 - 1134
SICI:
0148-396X(200105)48:5<1128:EOMHOE>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; TRAUMATIC BRAIN INJURY; COMPLETE COMPRESSION ISCHEMIA; ENERGY-STATE; RAT-BRAIN; POSTISCHEMIC HYPOTHERMIA; GLYCOLYTIC METABOLITES; BARRIER DISRUPTION; NEURONAL DAMAGE; AMINO-ACIDS;
Keywords:
apparent diffusion coefficient mapping; brain edema; ischemia; magnetic resonance imaging; moderate hypothermia; subarachnoid hemorrhage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Piepgras, A Klinikum Hannover Nordstadt, Neurochirurg Klin, Halthoffstr 41, D-30167 Hannover, Germany Klinikum Hannover Nordstadt Halthoffstr 41 Hannover Germany D-30167
Citazione:
A. Piepgras et al., "Effect of moderate hypothermia on experimental severe subarachnoid hemorrhage, as evaluated by apparent diffusion coefficient changes", NEUROSURGER, 48(5), 2001, pp. 1128-1134

Abstract

OBJECTIVE: The aims of this study were to investigate the early changes inthe mean apparent diffusion coefficient (ADC) after severe subarachnoid hemorrhage (SAH), as a marker of ischemic damage, and to examine the effects of moderate hypothermia, induced at various time points, on ADC changes. METHODS: ADC maps were calculated from diffusion-weighted, blipped-epi, spin echo, magnetic resonance imaging sequences (2.35-T BIOSPEC 24/40 scanner; Bruker Medizin Technik GmbH, Karlsruhe, Germany) for 21 anesthetized (0.45-1% halothane, temperature-adjusted/30% oxygen/69% nitrogen) and ventilated Wistar rats. After baseline scanning, bolus injection of 0.5 mi of autologous arterial blood or artificial cerebrospinal fluid (control group), intothe cisterna magna, was performed. Serial scanning was performed for 3 hours after injection, using normothermic or hypothermic (32 degreesC) rats. In an additional series of experiments, hypothermia was initiated either immediately or 60 minutes after normothermic SAH. The water contents of the removed brains were calculated using the wet/dry weight method. RESULTS: The ADC values did not change in the control group but decreased to 88.6 +/- 5.2% (P < 0.05 versus baseline) after SAH and remained significantly decreased throughout the experiment in normothermia. An injection of blood during hypothermia caused an initial decrease in ADC to 96.1 <plus/minus> 5.6% (P < 0.05 versus baseline); values continuously increased and reached normal levels within 60 minutes. Delayed hypothermia also normalized ADC values within the observation period. The brain water content in the control group was 80.3 <plus/minus> 0.1%, that after SAH in normothermia was 81.1 +/- 0.7%, and that after SAH in hypothermia was 79.3 +/- 0.5%. CONCLUSION: This model of severe SAH in rats causes significant ADC changes, which are reversible by application of moderate hypothermia even when itis induced after a 60-minute delay. These findings support the concept of moderate hypothermia exerting a neuroprotective effect in severe SAH.

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Documento generato il 01/12/20 alle ore 08:08:21