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Titolo:
Effects of flunarizine on cadmium-induced Purkinje cell loss in rats
Autore:
Genc, H; Bagirici, F; Cakir, A; Demir, S; Tan, F;
Indirizzi:
Ondokuz Mayis Univ, Fac Med, Dept Physiol, TR-55139 Samsun, Turkey OndokuzMayis Univ Samsun Turkey TR-55139 ysiol, TR-55139 Samsun, Turkey Ondokuz Mayis Univ, Fac Educ, Dept Biol, TR-55139 Samsun, Turkey Ondokuz Mayis Univ Samsun Turkey TR-55139 Biol, TR-55139 Samsun, Turkey
Titolo Testata:
NEUROSCIENCE RESEARCH COMMUNICATIONS
fascicolo: 2, volume: 28, anno: 2001,
pagine: 131 - 134
SICI:
0893-6609(200103/04)28:2<131:EOFOCP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-CHANNEL BLOCKERS; ANTICONVULSANT DRUGS; GUINEA-PIG; ISCHEMIA; BRAIN; CORTEX; MICE; NEUROTOXICITY; HIPPOCAMPAL; BICUCULLINE;
Keywords:
cerebellum; cell death; cadmium; flunarizine; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Bagirici, F Ondokuz Mayis Univ, Fac Med, Dept Physiol, TR-55139 Samsun, Turkey Ondokuz Mayis Univ Samsun Turkey TR-55139 139 Samsun, Turkey
Citazione:
H. Genc et al., "Effects of flunarizine on cadmium-induced Purkinje cell loss in rats", NEUROSC R C, 28(2), 2001, pp. 131-134

Abstract

The effects of the calcium channel blocker flunarizine on cadmium-induced Purkinje cell loss in the cerebellum of rats were investigated. Rats were divided into three groups: control, cadmium, and cadmium+flunarizine. Salinewas administered intracortically to the first group, cadmium sulphate (0.0021 mg/kg) to the second group, and cadmium sulphate (0.0021 mg/kg) and flunarizine (1 mg/kg) to the third group. All rats were observed for 1 week, but only the rats in the third group were injected with flunarizine (10 mg/kg/day, i.p.) during this period. One week later, all rats were perfused intracardially. Series of frontal sections from the cerebellum were stained with thionin. Purkinje cells were counted at x 400 magnification under a light microscope. Purkinje cell density was 20.62 +/- 0.68/mm (average +/- SD) in the right hemisphere and 20.56 +/- 0.79/mm in the left hemisphere of thecontrol group; 14.23 +/- 0.34/mm in the right hemisphere and 14.17 +/- 0.44/mm in the left hemisphere of the cadmium group; and 18.46 +/- 0.59/mm in right hemisphere and 17.76 +/- 0.84/mm in left hemisphere of the cadmium+flunarizine group. The results suggest that flunarizine may attenuate Purkinje cell death caused by cadmium (P < 0.05).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:37:56