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Titolo:
Acute effects of fluoxetine on inhibitory avoidance consolidation in male and female OF1 mice
Autore:
Monleon, S; Casino, A; Vinader-Caerols, C; Arenas, MC;
Indirizzi:
Univ Valencia, Fac Psicol, Area Psicobiol, E-46010 Valencia, Spain Univ Valencia Valencia Spain E-46010 Psicobiol, E-46010 Valencia, Spain
Titolo Testata:
NEUROSCIENCE RESEARCH COMMUNICATIONS
fascicolo: 2, volume: 28, anno: 2001,
pagine: 123 - 130
SICI:
0893-6609(200103/04)28:2<123:AEOFOI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEX-DIFFERENCES; MEMORY; ANTIDEPRESSANTS; DEPRESSION; ENHANCEMENT; RETENTION; SYSTEMS;
Keywords:
fluoxetine; inhibitory avoidance; memory; locomotor activity; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Monleon, S Univ Valencia, Fac Psicol, Area Psicobiol, Blasco Ibanez 21, E-46010 Valencia, Spain Univ Valencia Blasco Ibanez 21 Valencia Spain E-46010 a, Spain
Citazione:
S. Monleon et al., "Acute effects of fluoxetine on inhibitory avoidance consolidation in male and female OF1 mice", NEUROSC R C, 28(2), 2001, pp. 123-130

Abstract

The effects of acute administration of fluoxetine on memory consolidation using an inhibitory avoidance task were investigated in male and female OF1mice. Several doses of this antidepressant (5, 10, and 20 mg/kg) were intraperitoneally administered immediately after the training session. The testsession was carried out four days later and response latencies were measured in both sessions. The results showed that the highest dose of fluoxetinesignificantly increased response latencies of inhibitory avoidance compared with the lowest dose and the control group. Sex differences in this task were observed, females showing a better performance. But the drug's effectswere not sexually dimorphic. These sex differences were present in controlanimals, and they remained at every dose of fluoxetine. It is concluded that acute administration of fluoxetine did not impair inhibitory avoidance learning and it could be a better choice in depression and other disorders associated with memory deficits.

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Documento generato il 19/01/20 alle ore 11:46:58