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Titolo:
Proconvulsant effects of central and peripheral administration of L-name on penicillin-induced epilepsy in rats
Autore:
Bagirici, F; Marangoz, C;
Indirizzi:
Ondokuz Mayis Univ, Fac Med, Dept Physiol, TR-55139 Samsun, Turkey OndokuzMayis Univ Samsun Turkey TR-55139 ysiol, TR-55139 Samsun, Turkey
Titolo Testata:
NEUROSCIENCE RESEARCH COMMUNICATIONS
fascicolo: 2, volume: 28, anno: 2001,
pagine: 107 - 114
SICI:
0893-6609(200103/04)28:2<107:PEOCAP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; ACID-INDUCED SEIZURES; INDUCED EPILEPTIFORM ACTIVITY; DEEP PREPIRIFORM CORTEX; KAINIC ACID; NERVOUS-SYSTEM; NMDA RECEPTORS; IN-VITRO; KAINATE; ANTICONVULSANT;
Keywords:
nitric oxide; L-NAME; epileptiform activity; penicillin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Bagirici, F Ondokuz Mayis Univ, Fac Med, Dept Physiol, TR-55139 Samsun, Turkey Ondokuz Mayis Univ Samsun Turkey TR-55139 139 Samsun, Turkey
Citazione:
F. Bagirici e C. Marangoz, "Proconvulsant effects of central and peripheral administration of L-name on penicillin-induced epilepsy in rats", NEUROSC R C, 28(2), 2001, pp. 107-114

Abstract

The effect of Nm-nitro L-arginine methyl ester (L-NAME) on penicillin-induced epileptiform activity was investigated in anaesthetized Wistar rats. Approximately 39.1 +/- 5.7 min after penicillin G (3 million U/kg, i.p.) administration, large amplitude intermittent sharp waves appeared in the electrocorticogram. L-NAME (60 mg/kg, i.p.) injection 30 min before penicillin G administration significantly reduced the latency of epileptiform activity (12.9 +/- 3.2). In other groups, when the epileptiform activity reached maximum levels, administration of L-NAME (300 mug/2 pi, i.c.v.) significantly increased the frequency of epileptic spikes, while saline and D-NAME (N-pi-nitro D-arginine methyl ester, 300 mug, i.c.v.) were completely ineffective. These results suggest that L-NAME has proconvulsant effects and NO may be an endogenous anticonvulsantsubstance.

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Documento generato il 30/05/20 alle ore 15:01:32