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Titolo:
Alteration in glycoconjugate metabolism in CNS disorders - Role of isoprenoid pathway
Autore:
Kurup, RKA; Devi, D; Augustine, J; Kurup, PA;
Indirizzi:
Med Coll Hosp, Dept Neurol, Trivandrum 695011, Kerala, India Med Coll Hosp Trivandrum Kerala India 695011 andrum 695011, Kerala, India Med Coll Hosp, Dept Biochem, Trivandrum 695011, Kerala, India Med Coll Hosp Trivandrum Kerala India 695011 andrum 695011, Kerala, India
Titolo Testata:
NEUROSCIENCE RESEARCH COMMUNICATIONS
fascicolo: 2, volume: 28, anno: 2001,
pagine: 95 - 106
SICI:
0893-6609(200103/04)28:2<95:AIGMIC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; MULTIPLE-MYELOMA; GLYCOSAMINOGLYCANS; UBIQUINONE; SCLEROSIS; DOLICHOL; ACIDS;
Keywords:
dolichol; digoxin; glycosaminoglycans; glycoproteins; glycolipids; hydroxy methyl glutaryl coenzyme A (HMG CoA) reductase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Kurup, PA Med Coll Hosp, Dept Neurol, Trivandrum 695011, Kerala, India MedColl Hosp Trivandrum Kerala India 695011 011, Kerala, India
Citazione:
R.K.A. Kurup et al., "Alteration in glycoconjugate metabolism in CNS disorders - Role of isoprenoid pathway", NEUROSC R C, 28(2), 2001, pp. 95-106

Abstract

The isoprenoid pathway which is upregulated in neuropsychiatric disorders produces two metabolites which can regulate glycoconjugate metabolism - dolichol (required for N-glycosylation) and digoxin (endogenous membrane sodium-potassium ATPase inhibitor producing magnesium depletion). It is known that Mg++ deficiency can influence glycoconjugate metabolism. The results showed an increase in the concentration of serum total glycosaminoglycan (GAG), glycolipids and carbohydrate component of glycoproteins and a decrease inthe total GAG and carbohydrate component of glycoproteins in the Red bloodcell (RBC) membrane suggesting their reduced incorporation into the membrane. The pattern of change in individual GAG in the serum was different, however heparan sulphate (WS) and chondroitin sulphate (ChS) increased in mostof the disorders studied. The activity of GAG degrading enzymes and glycohydrolases showed significant increase in the serum in all the groups suggesting reduced lysosomal stability consequent to defective lysosomal membraneformation. The importance of altered glycoconjugate metabolism in the pathogenesis of multiple sclerosis, Parkinson's disease, schizophrenia, epilepsy and CNS gliomas is stressed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:26:22