Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cultured glial cells are resistant to the effects of motor neurone disease-associated SOD1 mutations
Autore:
Williams, RE; Cookson, MR; Fray, AE; Manning, PM; Menzies, FM; Figlewicz, DA; Shaw, PJ;
Indirizzi:
Univ Newcastle Upon Tyne, Sch Med, Dept Neurol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Univ Newcastle Upon Tyne Newcastle Upon Tyne Tyne & Wear England NE1 7RU Univ Rochester, Dept Neurol, Rochester, NY USA Univ Rochester Rochester NY USA ochester, Dept Neurol, Rochester, NY USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2-3, volume: 302, anno: 2001,
pagine: 146 - 150
SICI:
0304-3940(20010420)302:2-3<146:CGCART>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; SUPEROXIDE-DISMUTASE; OXIDATIVE STRESS; NEURAL CELLS; SPINAL-CORD; DAMAGE; ASTROCYTES; GLUTAMATE; PROTEIN; MODEL;
Keywords:
ALS; motor neurone disease; SOD1 mutations; oxidative stress; glial cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Shaw, PJ Univ Sheffield, Sch Med, Dept Neurol, E Floor,Beech Hill Rd, Sheffield S102RX, S Yorkshire, England Univ Sheffield E Floor,Beech Hill Rd Sheffield S Yorkshire England S10 2RX
Citazione:
R.E. Williams et al., "Cultured glial cells are resistant to the effects of motor neurone disease-associated SOD1 mutations", NEUROSCI L, 302(2-3), 2001, pp. 146-150

Abstract

Free radical damage has been implicated in the pathophysiology of motor neurone disease (MND); mutations have been identified in the gene encoding Cu/Zn superoxide dismutase (SOD1). There is evidence that glial cell dysfunction may contribute to motor neurone injury, but the exact role of glial cells in MND has yet to be established. The aim of this study was to determinewhether expression of mutant SOD1 affects the response of glia to oxidative stress. Stable C6 glioma cells expressing mutant SOD1 and cortical astrocyte cultures from G93A-SOD1 transgenic mice were exposed to: xanthine/xanthine oxidase; hydrogen peroxide; A23187 and 3-morpholinosydonimine. Cell viability was measured using the 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Neither C6 glioma cells nor cortical astrocytes expressing mutant SOD1 were more susceptible to any of the free radical generating systems compared to control cells. These results suggest that astrocytes are resistant to the toxic effects of mutant SOD1 widely reported for neuronal cells. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:37:35