Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Mouse nestin protein localizes in growth cones of P19 neurons and cerebellar granule cells
Autore:
Yan, Y; Yang, J; Bian, W; Jing, NH;
Indirizzi:
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China Chinese Acad Sci Shanghai Peoples R China 200031 200031, Peoples R China
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2-3, volume: 302, anno: 2001,
pagine: 89 - 92
SICI:
0304-3940(20010420)302:2-3<89:MNPLIG>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERMEDIATE FILAMENT PROTEIN; ORGANIZATION; NEUROFILAMENT; IDENTIFICATION; EXPRESSION; ELONGATION; DYNAMICS; GUIDANCE; SYSTEM; ACTIN;
Keywords:
growth cone; nestin; growth-associated protein-43; P19 neurons; cerebellar granule cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Jing, NH Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China Chinese Acad Sci 320 Yue Yang Rd Shanghai Peoples R China 200031
Citazione:
Y. Yan et al., "Mouse nestin protein localizes in growth cones of P19 neurons and cerebellar granule cells", NEUROSCI L, 302(2-3), 2001, pp. 89-92

Abstract

The neuronal growth cone, a highly motile structure at the distal tip of growing axons, contains filamentous actin and microtubules as its main cytoskeletal components. Using immunocytochemistry, we observed that nestin, which is the predominant intermediate filament protein in neuroepithelial cells and young neurons of the developing brain, appears to be strongly expressed in neurites and growth cones of neurons differentiating from P19 embryonic carcinoma cells in vitro. Double-staining of nestin and microtubule-associated protein-2 as well as nestin and growth-associated protein-43 revealed that nestin protein localizes in neurites and the central regions of growth cones of primary cultures of cerebellar granule cells from postnatal day6 mice. These results suggest a role for nestin in growth cone guidance during axon elongation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 14:15:29