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Titolo:
Dopamine transporter-immunoreactive axons in the mediodorsal thalamic nucleus of the macaque monkey
Autore:
Melchitzky, DS; Lewis, DA;
Indirizzi:
Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 sychiat, Pittsburgh, PA 15213 USA Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 eurosci, Pittsburgh, PA 15213 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 103, anno: 2001,
pagine: 1033 - 1042
SICI:
0306-4522(2001)103:4<1033:DTAITM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; DORSOLATERAL PREFRONTAL CORTEX; SUB-CORTICAL STRUCTURES; TYROSINE-HYDROXYLASE; RHESUS-MONKEY; HUMAN BRAIN; RAT-BRAIN; WORKING-MEMORY; I-125 EPIDEPRIDE; CEREBRAL-CORTEX;
Keywords:
deopamine beta-hydroxylase; prefrontal cortex; schizophrenia; tyrosine hydroxylase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Lewis, DA Univ Pittsburgh, Dept Psychiat, 3811 Ohara St, Pittsburgh, PA 15213 USA Univ Pittsburgh 3811 Ohara St Pittsburgh PA USA 15213 15213 USA
Citazione:
D.S. Melchitzky e D.A. Lewis, "Dopamine transporter-immunoreactive axons in the mediodorsal thalamic nucleus of the macaque monkey", NEUROSCIENC, 103(4), 2001, pp. 1033-1042

Abstract

The reciprocal connections between the mediodorsal thalamic nucleus and the prefrontal cortex participate in a circuit that is essential to a number of higher cognitive processes. Projections from the dopamine-containing cells of the ventral mesencephalon to the prefrontal cortex are also critical for these cognitive abilities. It is unclear, however, whether dopamine axons innervate the mediodorsal thalamic nucleus in primates. In order to address this question, we examined the distribution of dopamine transporter-immunoreactive axons in the mediodorsal thalamic nucleus of macaque monkeys. Labeled axons were distributed quite heterogeneously in this nucleus, and did not strictly follow cytoarchitectonic subdivision boundaries. The ventraland lateral portions of the mediodorsal thalamic nucleus, which include parts of the parvicellular and multiform subdivisions, had the highest density of dopamine transporter-immunoreactive axons. In contrast, the dorsomedial portion, which included primarily the magnocellular subdivision, had the lowest density of labeled axons. In both lightly and densely innervated portions of the nucleus, small, dense clusters of dopamine transporter-immunoreactive axons were present. Axons immunoreactive for tyrosine hydroxylase were distributed in a pattern very similar to that of dopamine transporter-labeled axons. In contrast, noradrenergic axons, as revealed by dopamine beta-hydroxylase immunoreactivity, were present in higher density and were more evenly distributed throughout the mediodorsal thalamic nucleus. This dopamine innervation of the mediodorsal thalamic nucleus reveals another possible anatomical substrate through which dopamine may influence the cognitive functions mediated by thalamo-prefrontal circuitry. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/11/19 alle ore 02:31:55