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Titolo:
Prenatal glucocorticoid modifies hypothalamo-pituitary-adrenal regulation in prepubertal guinea pigs
Autore:
Dean, F; Yu, C; Lingas, RI; Matthews, SG;
Indirizzi:
Univ Toronto, Fac Med, Dept Physiol, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 ysiol, Toronto, ON M5S 1A8, Canada Univ Toronto, Fac Med, Dept Obstet & Gynecol, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 necol, Toronto, ON M5S 1A8, Canada
Titolo Testata:
NEUROENDOCRINOLOGY
fascicolo: 3, volume: 73, anno: 2001,
pagine: 194 - 202
SICI:
0028-3835(200103)73:3<194:PGMHRI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; DEXAMETHASONE TREATMENT; BRAIN; RAT; GROWTH; AXIS; PROOPIOMELANOCORTIN; CORTICOSTEROIDS; PREGNANCY; RESPONSES;
Keywords:
adrenal steroids; adrenal steroid receptors; hippocampus; prenatal imprinting; guinea pig;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Matthews, SG Univ Toronto, Fac Med, Dept Physiol, Med Sci Bldg,1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada Univ Toronto Med Sci Bldg,1 Kings Coll Circle Toronto ON Canada M5S 1A8
Citazione:
F. Dean et al., "Prenatal glucocorticoid modifies hypothalamo-pituitary-adrenal regulation in prepubertal guinea pigs", NEUROENDOCR, 73(3), 2001, pp. 194-202

Abstract

We hypothesized that exposure to synthetic glucocorticoid during rapid brain growth (d50-52, birth = 68 days) in fetal guinea pigs modifies hypothalamo-pituitary-adrenal (HPA) function after birth, and that this involves changes in central corticosteroid receptor regulation. On the basis of our previous studies, we proposed that this effect is sex-specific. Pregnant guinea pigs were treated with dexamethasone (1 mg/kg) or vehicle on d50-51 of gestation, and juvenile offspring were euthanized at rest or following isolation stress on postnatal day 18. Dexamethasone increased the length of gestation (1.5 days) and altered body and organ (brain, heart, adrenal) growth. Resting plasma cortisol concentrations were significantly elevated in youngmale, but not female guinea pigs exposed to dexamethasone as fetuses. In female offspring born to dexamethasone-treated mothers, cortisol responses to isolation stress were attenuated. In males, elevated basal cortisol levels were not increased further by isolation. In the brain, hippocampal glucocorticoid receptor (GR) mRNA levels were significantly lower (10-25%) in females exposed to dexamethasone in utero. In contrast, GR mRNA levels were elevated (10-20%) in males from this prenatal treatment group. Mineralocorticoid receptor mRNA in the limbic system and GR mRNA levels in the pars distalis were unaffected. Proopiomelanocortin mRNA was significantly lower (30%)in the male pars intermedia following dexamethasone exposure. In conclusion, prenatal glucocorticoid exposure affects growth and HPA function as wellas limbic and hypothalamic GR expression in juvenile offspring, and these effects are highly sex-specific. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 01:24:42