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Titolo:
Lactation alters gamma-aminobutyric acid neuronal activity in the hypothalamus and cerebral cortex in the rat
Autore:
Kornblatt, JJ; Grattan, DR;
Indirizzi:
Univ Otago, Sch Med Sci, Dept Anat & Struct Biol, Dunedin, New Zealand Univ Otago Dunedin New Zealand Anat & Struct Biol, Dunedin, New Zealand Univ Otago, Ctr Res Neurosci, Dunedin, New Zealand Univ Otago Dunedin New Zealand , Ctr Res Neurosci, Dunedin, New Zealand
Titolo Testata:
NEUROENDOCRINOLOGY
fascicolo: 3, volume: 73, anno: 2001,
pagine: 175 - 184
SICI:
0028-3835(200103)73:3<175:LAGANA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUTEINIZING-HORMONE SECRETION; PULSATILE LH-SECRETION; SUPRAOPTIC NUCLEUS; GABA CONCENTRATIONS; INDUCED INHIBITION; PROLACTIN-RELEASE; GABAERGIC NEURONS; OXYTOCIN NEURONS; BRAIN-REGIONS; PREOPTIC AREA;
Keywords:
suckling; gonadotropins; prolactin; gonadotropin-releasing hormone; gamma-aminobutyric acid; lactation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Grattan, DR Univ Otago, Sch Med Sci, Dept Anat & Struct Biol, POB 913, Dunedin, New Zealand Univ Otago POB 913 Dunedin New Zealand Dunedin, New Zealand
Citazione:
J.J. Kornblatt e D.R. Grattan, "Lactation alters gamma-aminobutyric acid neuronal activity in the hypothalamus and cerebral cortex in the rat", NEUROENDOCR, 73(3), 2001, pp. 175-184

Abstract

gamma -Aminobutyric acid (GABA) neurons terminating in the hypothalamus have been implicated in the neuroendocrine regulation of reproductive hormones, particularly luteinizing hormone (LH) and prolactin. The aim of this study was to examine whether GABAergic neuronal activity in the hypothalamus was modified during lactation, and whether any observed changes correlated with changes in secretion of these hormones. Animals were divided into threeexperimental groups: diestrous controls, lactating with pups present (withpups), and lactating with pups removed for 4 h (without pups). Animals were decapitated either without treatment, or 60 min after inhibition of GABA degradation by aminooxyacetic acid (AOAA) (100 mg/kg, i.p.). The rate of GABA accumulation in the tissue after AOAA is a measure of GABA turnover. GABA turnover was estimated in 13 microdissected brain regions, and serum prolactin and LH measured by radioimmunoassay. Suckling was associated with significantly increased prolactin and significantly decreased LH compared withdiestrous rats. In lactating rats with pups, GABA turnover was significantly increased in the cingulate cortex compared with diestrous rats. GABA turnover was significantly increased in the ventrolateral preoptic nucleus of lactating rats with pups compared with diestrous rats or lactating rats without pups. There was significantly lower GABA turnover in the anterior hypothalamic area, ventromedial and dorsomedial hypothalamic nuclei in lactating rats without pups compared with diestrous rats. There were no significantchanges in other brain regions examined. The results demonstrate that activity of GABAergic neurons in specific parts of the hypothalamus and cerebral cortex is altered during lactation. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 16:34:43