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Titolo:
Long-term therapy with glatiramer acetate in multiple sclerosis: effect onT-cells
Autore:
Ragheb, S; Abramczyk, S; Lisak, D; Lisak, R;
Indirizzi:
Wayne State Univ, Dept Neurol, Div Neuroimmunol, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 Neuroimmunol, Detroit, MI 48201 USA Wayne State Univ, Sch Med, Dept Immunol & Microbiol, Detroit, MI 48201 USAWayne State Univ Detroit MI USA 48201 & Microbiol, Detroit, MI 48201 USA Wayne State Univ, Sch Med, Detroit Med Ctr, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 roit Med Ctr, Detroit, MI 48201 USA
Titolo Testata:
MULTIPLE SCLEROSIS
fascicolo: 1, volume: 7, anno: 2001,
pagine: 43 - 47
SICI:
1352-4585(200102)7:1<43:LTWGAI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN BASIC-PROTEIN; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; SYNTHETIC COPOLYMER-1; RELAPSE RATE; COPAXONE(R); DISABILITY; INHIBITION; RESPONSES; COP-1;
Keywords:
multiple sclerosis; T-cells; glatiramer acetate; immune system; tolerance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Ragheb, S Wayne State Univ, Dept Neurol, Div Neuroimmunol, 3128 Elliman Bldg,421 E Canfield Ave, Detroit, MI 48201 USA Wayne State Univ 3128 Elliman Bldg,421 E Canfield Ave Detroit MI USA 48201
Citazione:
S. Ragheb et al., "Long-term therapy with glatiramer acetate in multiple sclerosis: effect onT-cells", MULT SCLER, 7(1), 2001, pp. 43-47

Abstract

Glatiramer acetate (GA) is an immunotherapeutic drug for multiple sclerosis (MS). Several mechanisms of action have been demonstrated which target and effect T-cells that ore specific for myelin antigen epitopes. We measuredthe in vitro proliferation of GA-responsive T-cells from untreated MS patients and from normal healthy subjects; in addition, we determined the effect of prolonged GA therapy or interferon-beta therapy on the in vitro proliferation of GA-responsive T-cells of MS patients. We found that GA induces the proliferation of T-cells isolated from individuals who have not been previously exposed to GA, and that long-term in vivo therapy of MS patients with GA abrogates the GA-induced proliferative response of T-cells. In GA-treated patients, there is no evidence of generalized immunosuppression; both tetanus toroid and anti-CD3 induced proliferative responses remain unaffected We Propose that prolonged in vivo exposure to GA may result in the eventual induction of energy or deletion of a population of GA-responsive cells that may also be T-cells that ore pathogenic in MS. This mechanism of action, in addition to other mechanisms that have been demonstrated, suggests that GA has pleiotropic effects on the immune system in MS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:07:30