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Titolo:
Chlamydia pneumoniae in multiple sclerosis: humoral immune responses in serum and cerebrospinal fluid and correlation with disease activity marker
Autore:
Krametter, D; Niederwieser, G; Berghold, A; Birnbaum, G; Strasser-Fuchs, S; Hartung, HP; Archelos, JJ;
Indirizzi:
Karl Franzens Univ Graz, Dept Neurol, A-8036 Graz, Austria Karl Franzens Univ Graz Graz Austria A-8036 Neurol, A-8036 Graz, Austria Barmherzige Bruder Hosp, Dept Neurol, Graz, Austria Barmherzige Bruder Hosp Graz Austria r Hosp, Dept Neurol, Graz, Austria Karl Franzens Univ Graz, Inst Med Informat Stat & Documentat, Graz, Austria Karl Franzens Univ Graz Graz Austria t Stat & Documentat, Graz, Austria Minneapolis Clin Neurol, Multiple Sclerosis Treatment & Res Ctr, Minneapolis, MN USA Minneapolis Clin Neurol Minneapolis MN USA Res Ctr, Minneapolis, MN USA
Titolo Testata:
MULTIPLE SCLEROSIS
fascicolo: 1, volume: 7, anno: 2001,
pagine: 13 - 18
SICI:
1352-4585(200102)7:1<13:CPIMSH>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; INFECTION; CELLS; PATHOGENESIS; MS;
Keywords:
multiple sclerosis; chlamydia pneumoniae; antibody; serum; CSF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Archelos, JJ Karl Franzens Univ Graz, Dept Neurol, Auenbruggerpl 22, A-8036 Graz, Austria Karl Franzens Univ Graz Auenbruggerpl 22 Graz Austria A-8036
Citazione:
D. Krametter et al., "Chlamydia pneumoniae in multiple sclerosis: humoral immune responses in serum and cerebrospinal fluid and correlation with disease activity marker", MULT SCLER, 7(1), 2001, pp. 13-18

Abstract

Humoral immune responses to Chlamydia pneumoniae (C. pneumoniae) were studied in paired sera and cerebrospinal fluid (CSF) of patients with definite multiple sclerosis (MS) and other inflammatory and non-inflammatory neurological diseases. Seropositivity was not significantly different between these groups. However, C. pneumoniae-specific IgG titers were significantly higher in CSF of MS than in controls. Sixteen out of 52 seropositive MS patients (30.8%) showed intrathecal synthesis of C, pneumoniae-specific IgG but only one of 43 seropositive controls (2.3%). In MS, this was strongly associated with intrathecal synthesis of polyclonal IgG in 13/16 patients. However, these elevated C. pneumoniae antibody titers in CSF did not significantly correlate with disease duration, disease course, clinical or MRI disease activity disability or presence of oligoclonal IgG in MS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:26:52