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Titolo:
A meta-analysis of genomic screens in multiple sclerosis
Autore:
Pericak-Vance, MA; Rimmler, JB; Saunders, AM; Martin, ER; Haines, JL; Garcia, ME; Oksenberg, JR; Barcellos, LF; Lincoln, R; Goodkin, DE; Hauser, SL; Compston, DAS; Sawcer, SJ; Clayton, D; Jones, HB; Walker, N; Goodfellow, PPN; Bulman, D; Sadovnick, D; Ebers, GC; Dyment, D; Willer, C; Risch, N;
Indirizzi:
Vanderbilt Univ, Program Human Genet, Amer Grp, Nashville, TN 37240 USA Vanderbilt Univ Nashville TN USA 37240 Amer Grp, Nashville, TN 37240 USA Vanderbilt Univ, Dept Mol Physiol & Biophys, Nashville, TN USA Vanderbilt Univ Nashville TN USA ol Physiol & Biophys, Nashville, TN USA Univ Cambridge, Addenbrookes Hosp, DAS Compston, British Grp, Cambridge CB2 2QQ, England Univ Cambridge Cambridge England CB2 2QQ Grp, Cambridge CB2 2QQ, England Univ Oxford, Radcliffe Infirm, Dept Clin Neurol, Oxford OX2 6HE, England Univ Oxford Oxford England OX2 6HE Clin Neurol, Oxford OX2 6HE, England Duke Univ, Med Ctr, Dept Med, Ctr Human Genet, Durham, NC USA Duke Univ Durham NC USA d Ctr, Dept Med, Ctr Human Genet, Durham, NC USA Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Inst Publ Hlth, MRC, Biostat Unit, Cambridge CB2 2SR, England Inst Publ Hlth Cambridge England CB2 2SR nit, Cambridge CB2 2SR, England Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England Univ Cambridge Cambridge England CB2 3EH net, Cambridge CB2 3EH, England Ottawa Gen Hosp, Res Inst, Ottawa, ON K1H 8L6, Canada Ottawa Gen Hosp Ottawa ON Canada K1H 8L6 Inst, Ottawa, ON K1H 8L6, Canada Univ British Columbia, Dept Med Genet, Vancouver, BC V5Z 1M9, Canada Univ British Columbia Vancouver BC Canada V5Z 1M9 ver, BC V5Z 1M9, Canada Univ Oxford, Radcliffe Infirm, Dept Clin Neurol, Oxford OX2 6HE, England Univ Oxford Oxford England OX2 6HE Clin Neurol, Oxford OX2 6HE, England Stanford Univ, Dept Genet, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 v, Dept Genet, Stanford, CA 94305 USA
Titolo Testata:
MULTIPLE SCLEROSIS
fascicolo: 1, volume: 7, anno: 2001,
pagine: 3 - 11
SICI:
1352-4585(200102)7:1<3:AMOGSI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC-BASIS; SUSCEPTIBILITY; COMPLEX; LINKAGE; LOCI; GUIDELINES;
Keywords:
multiple sclerosis; meta-analysis; linkage; genome screen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Haines, JL Vanderbilt Univ, Program Human Genet, Amer Grp, 221 Kirkland Hall, Nashville, TN 37240 USA Vanderbilt Univ 221 Kirkland Hall Nashville TN USA 37240 40 USA
Citazione:
M.A. Pericak-Vance et al., "A meta-analysis of genomic screens in multiple sclerosis", MULT SCLER, 7(1), 2001, pp. 3-11

Abstract

We combined the raw genotyping data from three large multiple sclerosis genome screens and Performed a global meta-analysis in order to compare and summarize the linkage results from the different studies. In alphabetical order, the screens provided data from 442 markers typed in 52 multiplex families with a total of 133 affected individuals (the American screen), 314 markers typed in 128 families with 264 affecteds (the British screen) and 257 markers typed in 61 families with a total of 139 affected subjects (the Canadian screen). Multipoint analysis of these data was performed using the GENEHUNTER program. The highest non-parametric linkage (NPL) score in the meta-analysis was observed on chromosome 1 7q 1 1 (NPL score 2.58), although this score foils short of genome-wide significance. A total of eight regionshad NPL scores greater than 2.0. One of the regions with on NPL score greeter than 2.0 was the HLA region on chromosome 6p21 (NPL=2.2). This region is known, from association studies, to be involved in MS susceptibility, butthe modest linkage result observed here suggests the encoded susceptibility effect is not large compared with the high familial recurrence in MS (lambda (s)approximate to 20). Overall, our linkage results suggest that MS is likely to be multigenic in its genetic susceptibility.

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Documento generato il 05/04/20 alle ore 07:01:38