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Titolo:
PROTECTIVE EFFECT OF ZINC GLUCONATE ON CHEMICALLY-INDUCED GASTRIC-ULCER
Autore:
BANDYOPADHYAY B; BANDYOPADHYAY SK;
Indirizzi:
UNIV CALCUTTA,COLL MED,DEPT BIOCHEM,244-B,ACHARYA JC BOSE RD CALCUTTA700020 W BENGAL INDIA UNIV CALCUTTA,COLL MED,DEPT BIOCHEM CALCUTTA 700020 W BENGAL INDIA
Titolo Testata:
INDIAN JOURNAL OF MEDICAL RESEARCH
, volume: 106, anno: 1997,
pagine: 27 - 32
SICI:
0971-5916(1997)106:<27:PEOZGO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUCOSAL INJURY; ACEXAMATE;
Keywords:
CYTOPROTECTION; GASTRIC ACID SECRETION; GASTRIC H+ TRANSPORT; GASTRIC ULCER; MUCOSAL BARRIER; ZINC GLUCONATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
B. Bandyopadhyay e S.K. Bandyopadhyay, "PROTECTIVE EFFECT OF ZINC GLUCONATE ON CHEMICALLY-INDUCED GASTRIC-ULCER", INDIAN JOURNAL OF MEDICAL RESEARCH, 106, 1997, pp. 27-32

Abstract

This study was undertaken in rats to ascertain the role of zinc as anantiulcerogenic agent employing its more bioavailable gluconate derivative. Pretreatment with zinc gluconate 10mg/kg body wt orally for three consecutive days, protected against alcohol induced gastric epithelial damage and also significantly prevented non-steroidal anti-inflammatory drugs (NSAID) induced gastric ulcer in rats. The enhanced levelsof mucus, and hexosamine and decreased acid output in the gastric secretion of zinc treated rats, increased the gastric mucosal barrier. Studies on the mechanism of action suggested the involvement of-SH groups in producing gastric antisecretory effect. Thus, zinc gluconate at >> 100 mu M concentrations inhibited H+-ion transport which could be reversed by incorporating beta-mercaptoethanol in the secretory solution (luminal side). On the other hand, beta-mercaptoethanol added from the nutrient side showed no effect on the inhibition of H+-transport indicting that the implication of -SH groups may not be the sole factor. Zinc appeared to play a vital and multifaceted protective role in chemically induced gastric ulcer disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 04:26:46