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Titolo:
Large-scale monitoring of pleiotropic regulation of gene expression by theprokaryotic nucleoid-associated protein, H-NS
Autore:
Hommais, F; Krin, E; Laurent-Winter, C; Soutourina, O; Malpertuy, A; Le Caer, JP; Danchin, A; Bertin, P;
Indirizzi:
Inst Pasteur, Unite Regulat Express Genet, F-75724 Paris, France Inst Pasteur Paris France F-75724 t Express Genet, F-75724 Paris, France Genojole Inst Pasteur, Paris, France Genojole Inst Pasteur Paris FranceGenojole Inst Pasteur, Paris, France ESPCI, Lab Neurobiol & Divers Cellulaire, F-75005 Paris, France ESPCI Paris France F-75005 ol & Divers Cellulaire, F-75005 Paris, France
Titolo Testata:
MOLECULAR MICROBIOLOGY
fascicolo: 1, volume: 40, anno: 2001,
pagine: 20 - 36
SICI:
0950-382X(200104)40:1<20:LMOPRO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESCHERICHIA-COLI K-12; COMPLETE GENOME SEQUENCE; DNA-BINDING; DOMAIN ORGANIZATION; STRUCTURING PROTEIN; POLYACRYLAMIDE GELS; BACILLUS-SUBTILIS; ACID RESISTANCE; STRESS-RESPONSE; RNA-POLYMERASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Bertin, P Inst Pasteur, Unite Regulat Express Genet, 28 Rue Docteur Roux, F-75724 Paris, France Inst Pasteur 28 Rue Docteur Roux Paris France F-75724 s, France
Citazione:
F. Hommais et al., "Large-scale monitoring of pleiotropic regulation of gene expression by theprokaryotic nucleoid-associated protein, H-NS", MOL MICROB, 40(1), 2001, pp. 20-36

Abstract

Despite many years of intense work investigating the function of nucleoid-associated proteins in prokaryotes, their role in bacterial physiology remains largely unknown. The two-dimensional protein patterns were compared andexpression profiling was carried out on H-NS-deficient and wild-type strains of Escherichia coil K-12. The expression of approximately 5% of the genes and/or the accumulation of their protein was directly or indirectly altered in the hns mutant strain. About one-fifth of these genes encode proteinsthat are involved in transcription or translation and one-third are known to or were in silico predicted to encode cell envelope components or proteins that are usually involved in bacterial adaptation to changes in environmental conditions. The increased expression of several genes in the mutant resulted in a better ability of this strain to survive at low pH end high osmolarity than the wildtype strain. In particular, the putative regulator, YhiX, plays a central role in the H-NS control of genes required in the glutamate-dependent acid stress response. These results suggest that there is astrong relationship between the H-NS regulon and the maintenance of intracellular homeostasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:48:15