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Titolo:
Hypocretin receptor protein and mRNA expression in the dorsolateral pons of rats
Autore:
Greco, MA; Shiromani, PJ;
Indirizzi:
Vet Adm Med Ctr W Roxbury, W Roxbury, MA 02132 USA Vet Adm Med Ctr W Roxbury W Roxbury MA USA 02132 W Roxbury, MA 02132 USA Harvard Univ, Sch Med, W Roxbury, MA 02132 USA Harvard Univ W Roxbury MA USA 02132 niv, Sch Med, W Roxbury, MA 02132 USA
Titolo Testata:
MOLECULAR BRAIN RESEARCH
fascicolo: 1-2, volume: 88, anno: 2001,
pagine: 176 - 182
SICI:
0169-328X(20010331)88:1-2<176:HRPAME>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SLEEP; NARCOLEPSY; NEURONS; OREXINS;
Keywords:
hypocretin/orexin receptor; locus ceruleus; sleep-wakefulness; immunohistochemistry; in situ hybridization; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Greco, MA Vet Adm Med Ctr W Roxbury, 1400 VFW Pkwy, W Roxbury, MA 02132 USA Vet Adm Med Ctr W Roxbury 1400 VFW Pkwy W Roxbury MA USA 02132 A
Citazione:
M.A. Greco e P.J. Shiromani, "Hypocretin receptor protein and mRNA expression in the dorsolateral pons of rats", MOL BRAIN R, 88(1-2), 2001, pp. 176-182

Abstract

The hypocretins (also known as orexins) are hypothalamic peptides that have been implicated in feeding and sleep regulation. Previous reports have described the distribution of the mRNAs encoding two hypocretin receptors (HCRT-R), but the pattern of protein expression has not been investigated. Here we examine the distribution of the mRNA and protein for the HCRT receptorI (HCRT-R1) and HCRT receptor 2 (HCRT-R2) in the pontine brainstem and demonstrate that they are present in many pontine nuclei including those associated with REM sleep. Immunohistochemistry indicates that one or both of the receptor subtypes are expressed in the dorsal raphe, the lateral dorsal tegmental (LDT), the pedunculo pontine (PPT), the locus coeruleus (LC), the locus subcoeruleus, pontis oralis, Barrington's, the trigeminal complex (mesencephalic trigeminal and motor nucleus of the trigeminal nerve), the dorsal tegmental nucleus of Gudden (DTG), the ventral cochlear nucleus (VCA), trapezoid nucleus (TZ), pontine raphe nucleus and the pontine reticular formation. These regions have been shown to be involved in mastication, bladdercontrol, gastrointestinal function and in arousal. Given these projection sites and the functions associated with these sites, we suggest that HCRT may play a role in maintaining alertness and vigilance while the animal is engaged in consummatory behavior. (C) 2001 Elsevier Science BN. All rights reserved.

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Documento generato il 05/04/20 alle ore 04:12:32